The Boston Globe from Boston, Massachusetts • C8

C8 A A 1 4 2 0 1 9 Obituaries By Emily Langer WASHINGTON POST WASHINGTON Paul Tala- lay, a pharmacologist who spearheaded research in the 1990s that identified the can- cer-preventing properties of a compound found in broccoli, a discovery that was credited with bringing more scientific attention to ways of combating cancer before it takes hold, died Sunday at his home in Balti- more. He was 95. The cause was congestive heart failure, said his daughter Susan. Dr. Talalay, who was long as- sociated with the Johns Hop- kins University School of Medi- cine, spent the first decades of his career as an enzymologist, focused in particular on the proteins that interact with tes- tosterone.

He had encountered his first cancer patient in medical school and, by the 1980s, had begun to cultivate a thought that cancers of all sorts might actually be said Jed Fahey, who joined Dr. lab in 1993 and is now a professor at the Johns Hop- kins division of clinical phar- macology. Dr. Talalay oversaw research that revealed intriguing quali- ties of sulforaphane, a com- pound found in broccoli and in even greater quantities in broc- coli sprouts. When ingested, sulforaphane binds to a protein inside cells, said Philip Cole, a professor at Harvard Medical School who was a student of Dr.

That event sparks production of enzymes that help cells resist toxic substanc- es, including carcinogens. Consuming broccoli and other vegetables including kale and watercress helps the body create what Cole described as a against that might lead to cancer. He said Dr. research had a impact both in biomedi- cal research and in influencing what people eat to stay When Dr. Talalay began his work, he lamented the difficulty of convening even a few scien- tists interested in discussing di- etary means of preventing can- cer.

you can fill large con- vention halls with people who want to talk about Fahey said. are thou- sands of people who are really riding the crest of the waves that he and very few others Theresa Shapiro, a clinical pharmacologist at Johns Hop- kins, said that Dr. work been around long enough that it has penetrated into the Subsequent studies have shown potential benefits of sulforaphane for conditions far beyond cancer, including diabetes and autism. Paul Talalay was born to Russian parents in Berlin on March 31, 1923. His father was a chemist, and his mother was a homemaker.

The family, which was Jewish, fled Germany after Hitler came to power in 1933 and went first to England, where Dr. Talalay continued his schooling, and then to the Unit- ed States in 1940. Dr. Talalay received a bache- degree in molecular bio- physics from the Massachusetts Institute of Technology in 1944 and graduated from Yale School of Medicine in 1948. He joined the University of Chicago faculty and, in 1958, he received a grant of more than $500,000 from the American Cancer Society to support his research until he met retire- ment age.

It was at the time the largest grant ever be- stowed on a single individual. He came to Johns Hopkins in 1963 and remained on its facul- ty until his death. In addition to his daughter Susan of McLean, he leaves his wife of 66 years, the former Pamela Samuels, of Baltimore; a son, Tony, of Lutherville, two other daughters, Rachel of Vancouver and Sarah of Kuala Lumpur, Malaysia; and four grandchildren. In 1997, Dr. Talalay and Fa- hey founded Brassica Protec- tion Products to market brocco- li sprouts and other edibles with health benefits supported by their research.

Dr. Talalay, whose honors included mem- bership in the National Acade- my of Sciences, wore on his la- pel a silver pin representing a broccoli sprout. By Richard Goldstein NEW YORK TIMES NEW YORK Harry How- ell, the Hall of Fame defense- man who became one of hock- most durable figures, play- ing with the New York Rangers for 17 seasons in a career that spanned 24 seasons in two leagues, died Saturday in On- tario. He was 86. He had dementia and was living at a long-term-care facili- ty in Ancaster, outside his hometown, Hamilton.

When Mr. Howell joined the Rangers in 1952, he was among 14 rookies with the team that season. Most st ick around too long, but Mr. How- ell went on to play in 1,160 reg- ular-season games as a Ranger, still a team record. The Rangers were often lackluster in Mr.

play- ing days, but he joined with An- dy Bathgate on right wing and Gump Worsley in goal, his fel- low rookies and future Hall of Famers as well, to give their frustrated fans of the 1950s and early some hope. Mr. Howell won the Norris Trophy as the leading de- fenseman in the 1966-67 sea- son and he was a seven-time All-Star. Making his Ranger debut Oct. 18, 1952, facing the Maple Leafs in Toronto, Mr.

Howell scored on his first shot. But he was known as a at defenseman, usually sticking close to his blue line instead of looking for a chance to carry the puck up ice. At 6 foot 1 and 195 pounds or so, was a big guy for the time I he told John Hal- igan and John Kreiser in of My Life: New York (2008). I the type of guy to go run people. I could take them out of the play, but I going to skate 50 feet to hit Mr.

Howell finally broke the double-digit mark in goals scored in the 1966-67 season, when he had 12 goals and 28 assists. had Boom-Boom Geof- he once told the Hall of Fame in recalling that season. came to us from the Mon- treal Canadiens as a power-play specialist. pass him the puck on the right point. pass it back to me.

pass to him. Fi- nally, he said, you please shoot the A few of them went But for much of the city, the Rangers were often an after- thought, since they were regu- larly displaced from the Eighth Avenue Garden by more lucra- tive events. first two weeks of the season, the rodeo was booked Mr. Howell told the Hall, which inducted him in 1979. Kennel Club had dogs come in in February.

And then the circus came in right at the end of the season, and if we made the playoffs, be lucky to play two games at home, and the rest would be on the Henry Vernon Howell was born Dec. 28, 1932, in Hamil- ton, Ontario, where his father was a furrier. He joined the junior team at Guelph, Ontario, at 16, and was called up after three seasons there. Mr. Howell was the Ranger captain for two seasons in the 1950s and was voted the most popular player for three consecutive seasons in the 1960s.

He developed back prob- lems leading to spinal-fusion surgery before the 1969-70 sea- son. The Rangers offered him a management post, but he want- ed to continue playing and was sold to the Oakland Seals. After leaving the Rangers, Mr. Howell played another four seasons in the NHL, in the Bay Area and with the Los Angeles Kings, then moved to the World Hockey Association in 1973. He was a player-coach for the New York Golden Jersey Knights franchise for one sea- son, held the dual role when the team became the San Diego Mariners the following season, then concluded his career play- ing for the Calgary Cowboys, re- tiring in 1976 at 43.

He had 94 goals and 324 as- sists in the NHL, playing in 1,411 games. The Rangers never got be- yond the first round of the Stan- ley Cup playoffs when Mr. How- ell played for them. But he did have his name etched on the Cup, when he scouted for the Edmonton Oilers team that won the 1990 NHL champion- ship over the Boston Bruins. wish it could have been with the he remarked, a ring is still a Harry Howell, 86, hockey Hall of Fame defenseman ASSOCIATED Mr.

Howell waved to the crowd during a ceremony to retire his number 3 at Madison Square Garden in New York City. Paul Talalay; his research detailed foods By David Allen NEW YORK TIMES NEW YORK Michael Giel- en, a probing conductor who championed contemporary music and daring opera pro- ductions, died Friday at his home near Mondsee, Austria, east of Salzburg. He was 91. His death was confirmed by the German broadcaster SWR. Mr.

Gielen was active mostly in Europe, and one of his most important posts was as general music director of the Frankfurt Opera, a job he held for a de- cade starting in 1977. There he gave the German premieres of works by Luigi Nono and Alban Berg, revived overlooked works by Ferruccio Busoni and Franz Schreker, and invited the most ambitious directors to stage standard repertory. Working with the drama- turge Klaus Zehelein, Mr. Giel- en collaborated with Flimm, Harry Kupfer, Hans Neuenfels (including for a piv- otal in 1980), and Ruth Berghaus, who produced Wag- in notably symbol- ic fashion. In 1987, John Rockwell of The New York Times called the Frankfurt house most prominent exponent in the world of radical operatic stage direction and Mr.

Gielen was music direc- tor of the Cincinnati Symphony from 1980 to 1986, and his rad- ical programming there alienat- ed many. The next year he found a more congenial home back in Germany as chief con- ductor of the SWR Symphony Orchestra Baden-Baden, which became the SWR Symphony Orchestra Baden-Baden and Freiburg in 1996. That orchestra, backed by the resources of German state radio, gave him the freedom to promote the newest of music, especially at the Donauesch- inger Musiktage, a festival in southern Germany for contem- porary composers. He re- mained the perma- nent guest conductor after step- ping down in 1999, and later protested its merger with a sis- ter ensemble in Stuttgart. His SWR orchestra record- ings included a particularly lu- cid Mahler cycle, the sympho- nies of Beethoven and Brahms, and pieces by Bruckner, Strav- insky, and the composers of the Second Viennese School.

All prized detail and restraint over overt emotionality. a i Barenboim, who knew Mr. Giel- en for almost 70 years, said that Mr. Gielen had always been search of what he considered the musical truth, for the solu- tions that were given to him by the score and not by outside Mr. Gielen, who won the prestigious Ernst von Siemens Music Prize in 2010, viewed music as a disciplined intellec- tual pursuit that, more than providing comfort or entertain- ment, should shed light on the conflicts of the age, both in the world at large and in humani- inner life.

He particularly argued for confronting the hor- rors of the mid-20th century, represented by Auschwitz and Hiroshima. musical life does not con- vey this central experience of our time, which is the of he said, it is not a cultural life, but a cultural Michael Andreas Gielen was born July 20, 1927, in Dresden. His mother, Rose Steuermann, was an actress and soprano not- ed for her account of Schoen- his fa- ther, Josef Gielen, was a direc- tor at the state theater, entrusted by Richard Strauss with the premieres of and Schweigsame Though their mother was Jewish, Michael and his older sister, Carola, were baptized as Catholics in 1935, but the Nazis hounded them all the same. They followed their father first to Berlin, then to Vienna, and finally to Buenos Aires, in 1940. In Argentina, Mr.

Gielen was brought up among an exiled musical elite. He studied piano and composition under Erwin Leuchter, who had been Anton assistant, and heard the operatic repertoire under the baton of Fritz Busch. After he withdrew from the University of Buenos Aires in 1946 and became a coach at the Teatro Mr. Gielen re- hearsed und with soprano Kirsten Flagstad and conductor Erich Kleiber in 1948. When Wilhelm gler led Matthew Passion in 1950, Mr.

Gielen played the recitatives. Again following his father, Mr. Gielen returned to Europe in 1950, and to the Vienna State Opera, where he assisted Clemens Krauss, Dmitri Mitro- poulos, and Karl He con- tinued to compose, and his Variations for String Quartet (1949) were performed in Darmstadt, the home of post- war experimentalism. But podi- um opportunities proved more alluring, and Mr. Gielen be- came a staff conductor at the opera, leading everything from Mozart to Honegger.

As the music director of the Royal Swedish Opera from 1960 to 1965, Mr. Gielen over- saw a radical production of Prog- with Ingmar Bergman di- recting. As a guest conductor Mr. Gielen had a string of successes in famously challenging new music, overseeing the pre- mieres in 1965 alone of Gyorgy Requiem in Stockholm, Aribert in Kiel, and, in Cologne, Bernd Alois a major but ne- glected work of the last century. He was at the helm of the Bel- gian National Orchestra from 1969 to 1973 and the Nether- lands Opera from 1973 to 1975.

He leaves his wife, Helga Gielen, a soprano whom he married in 1957; their two chil- dren, Claudia and Lucas; and several grandchildren. Michael Gielen, renowned German conductor, at 91 You talk about many things with your loved ones: from day-to-day details to big events. Meaningful memorialization starts when loved ones talk about what matters most. Download a free brochure and Have the Talk of a Lifetime today. It can make the difference of a lifetime.

talkofal i fet ime.org Have theTalk of a Lifetime SM Remembered SHARE YOURMEMORIES ONOUR GUEST BOOK AT BOSTON.COM/OBITUARIES BostonGlobe.com WALLACE, Anne Harrison Passed peacefully in her home in Wash- ington, D.C., on February 11, 2019, at the age of 92. Born June 18, 1926, she was the eldest daughter of Leland Har- rison and Anne Coleman Harrison. On February 14, 1954, she married J. Berry Wallace, and raised two sons, William Leland and J. Berry, Jr.

(Jeb). Anne is survived by Leland and his wife Elsa, Jeb and his wife Teresa, two grand- daughters, Anne Dorrance Wallace and Emma Wallace McCollum (Ken), great-granddaughter, Rose McCollum, a niece, Anne Ayer, and nephews, Neil and Randolph Ayer. Her beloved husband, and her sister, Hellen Rice Ayer predeceased her. Anne was the daughter of a diplomat, and along with her younger sister, traveled extensively with her parents on all their various foreign postings. A longtime Washing- tonian, she made her summer home in Manchester By-the-Sea, MA.

She was an active member of the Sulgrave Club, Chevy Chase Club, Manchester Yacht Club, and New York Yacht Club. Being on the water was her favorite activity, and she and Berry cruised extensively in the Bahamas and along the east coast. She was completely devoted to her husband and her two boys, ensur- ing a wonderful and full life for all of them. A Memorial Service and recep- tion will be held March 18th, at 10:00 am, at: Joseph Sons, LLC, 5130 Wisconsin Ave. NW, Washington, DC 20016.

There will be an interment at Oak Hill Cemetery for the immediate family after the reception. Of Roslindale, passed away March 12, 2019. Daughter of the late Robert and Leone (Field) Davis. Beloved wife of the late Charles Wig- gins. Devoted mother of Caryn Hibbard and Denice Wiggins both of Worces- ter, Christine Bourett of Medway, and the late David Wiggins.

Loving grandmother of Caitlin Conley, and Ava and Evan Bourett. Dear sister of Lynne Keane of IL, Fred and Richard Davis both of West Roxbury, Susan and William Davis, both of Roslindale, and the late Robert Paul Davis, Jr. and Michael Davis. Also survived by many nieces and nephews. Visiting Hours at the P.E.

Murray F.J. Higgins, George F. Doherty Sons Funeral Home, 2000 Centre WEST ROXBURY, on Friday, March 15, from 4-8pm. Funeral Service in the Funeral Home on Saturday, March 16, at Interment pri- vate. In lieu of donations may be made in memory to the Muscular Dystrophy www.mda.

org in memory of her late son David Wiggins. For directions guestbook pemurrayfuneral.com WIGGINS, Pamela (Davis) P.E. Murray F.J. Higgins George F. Doherty Sons West Roxbury 617 325 2000 Of Stoughton, formerly of Dorchester, age 87, March 11.

Wife of the late Guy A. Mother of Stephen T. Tardanico of Carver, Debora T. DiBiasie of Saugus, Jeffrey P. Tardanico of Stoughton, Helene M.

Doherty of North Easton, Paula A. Tully of East Taunton, Chris- tine M. Cicero of Merrick, NY, Marie T. Kjelgaard of West Bridgewater, Neil J. Tardanico of Middleboro, and the late James M.

Tardanico. Sister of the late Jane M. McGrath. Also survived by 13 grandchildren, 3 great-grandchildren and many nieces and nephews. Funeral will be held from the Farley Funeral Home, 358 Park St.

(Rte. 27), STOUGHTON, on Tuesday, March 19, at 9 AM, followed by a Funeral Mass at Immaculate Conception Church, Stoughton at 10 AM. Visiting Hours Monday, from 4-7 PM. Interment will take place at Evergreen Cemetery, Stoughton. Donations in memory may be made to the MSPCA, 350 South Huntington Boston, MA 02130.

Obituary and directions at www.farleyfh.com TARDANICO, Barbara L. (Norton) Farley Funeral Home (781)344-2676 Age 68, of Milford MA, died Wednes- day, March 13, 2019. Beloved wife of Nicholas Zacchilli; loving mother of Michael Zacchilli and his wife Janel, Christopher Zacchilli and his wife Lynn and Peter Zacchilli; devoted daughter Viola (DeLuzio) Casasanta and the late Vittorio Casasanta; and loving sister of Jamie, wife of Michael Bruzina, also Paul Casasanta and Michael Casasanta. Her Funeral will be held Saturday, March 16, at 9am, from the Edwards Memorial Funeral Home, 44 Congress Street, MILFORD, MA, followed by a Mass of Christian Burial, at 10am, in Sacred Heart of Jesus Church (Upper Church), 7 East Main Street, Milford, MA. Visiting Hours will be Friday, March 15, from 5pm to 8pm.

Visit edwardsmemorialfuneralhome.com for complete obituary condolence book. In lieu of memorial dona- tions may be made to the Coach Linda Zacchilli Memorial Scholarship Fund, Milford Federal Bank, 246 Main Street, Milford, MA 01757 or to The Oliva Fund for Cancer Care, Milford Regional Healthcare Foundation, 14 Prospect Street, Milford, MA 01757. ZACCHILLI, Linda L. (Casasanta).