The Vancouver Sun from Vancouver, British Columbia, Canada • 1

FRIDAY, JANUARY 12, 2001 FINAL. Ww "ouversun.com TALE OF TIANAilivQi i A stunning new book, based on a Communist official's smuggled papers, dissects a massacre INSIGHT A13 7 Aqraraim The first genetically modified monkey 1" i'JJ-J considers capture of more wildlife Transfer of killer whale Bjossa forces search for new exhibit Creators hail hifaasahealth breakthrough; critics appalled By ROGER HIGHFIELD LONDON Scientists have created the world's first genetically modified monkey, a baby rhesus called ANDi. The feat could hasten the development of new treatments for a range of diseases, from diabetes and breast cancer to Parkinson's and HIV. "It's a special step," said Pro-fessor Gerald Schatten, the head of the Portland, Ore. team.

"We're at an extraordinary moment in the history of humans." But anti-vivisectionists fear that ANDi, who was born on Oct. 2 last year, will herald a surge in experiments on monkeys. They condemned the research as "abhorrent" and accused Schatten of "playing The work also raises the issue of whether similar techniques could be used to create geneti-cally modified humans. ANDi the name is "inserted DNA" spelled backwards received an extra marker gene, from a jellyfish, while he was still an unfertilized egg, making him the world's first geneticaUy modified non-human primate. "ANDi is robust and plays normally with his two roommates," said Schatten, of the Oregon Regional Primate Research Centre at the Oregon Health Sciences University in Portland, who reports the details in the current edition of the journal Science.

The technique used to make See ANDI CREATED A2 V'- If I -v By NICHOLAS READ Walruses, sea lions, arctic foxes, sea otters and even polar bears are among the animals being considering as replacement exhibits for Bjossa's Stanley Park pool once the orca is moved to San Diego's Sea World later this year. Vancouver Aquarium director John Nightingale said while there are no firm plans for the pool yet, he and his staff have considered using it to display animals either from the Arctic or theWest Coast. The Arctic display is much less likely, Nightingale said, and, given its possible inclusion of polar bears, far more controversial. Until its closure as a result of a 1993 plebiscite, the Stanley Park Zoo housed two polar bears. The last one, Tuk, died in 1997 at the age of 36.

Nightingale said the Arctic idea is "highly unlikely," but that it was aquarium practice "never to say never." "We kicked around some ideas," he said of the proposal, "but we never drew up a list of the animals it might include." Much more attractive, he said, is the idea of turning Bjossa's pool into an "interactive, customizable, multi-species" display of West Coast marine life, including Pacific white-sided dolphins, Stellar sea lions, harbour seals, fur seals, sea otters, and various sea and shore birds. The aquarium already has one white-sided dolphin, Whitew- ings, sharing the orca pool, as well as eight Stellar sea lions, three sea otters, and two harbour seals in other pools. But depending on what form the exhibit takes, more animals may be required, and Nightingale doesn't rule out catching them from the wild. ,7 "We made an agreement in 1996 that we will not catch any more cetaceans whales and dolphins from the wild, and we will honour that," he said. But the agreement does not include any other types of animals.

Park board chairwoman Laura McDermid said she was "shocked" to hear that wild animals could be caught for permanent display. See HUMANE SOCIETY A2 REUTERS Baby ANDi short for "inserted DNA" spelled backwards a genetically modified monkey. A new invention, but what is It? A new world in entertainment music on the Web legally Codenamed Ginger, gadget will 'sweep over the world' By BEN MacINTYRE WASHINGTON It may be the most important invention since the personal computer. It could change the world dramatically. It may be a huge hoax.

But since no one knows exactly what It is, apart from a handful of people who won't say, the mystery of It has become a scientific and publishing sensation in the United States. Harvard Business School Press has just paid an unprecedented $250,000 US Cdn) advance for a book about the secret invention, codenamed Ginger, which is being developed by Dean Kamen, a scientist, in his research laboratories in New Hampshire. Jeff Bezos and Steve Jobs, two high-technology magnates, are reported to be enthralled by the gadget, while John Doerr, a Silicon Valley venture capitalist, has invested in the project. Steve Kemper, a writer, has had exclusive access to Kamen for 18 months and has produced a carefully-written proposal to write a book about the invention, saying that the machine "will sweep over the world and change lives, cities and ways of He did not, however, say what the machine would do, and even the literary agent handling the book admits he has no clue what It is. In his proposal, Kemper writes coyly that Ginger will "profoundly affect our environment and the way people live worldwide.

See SECRET INVENTION All Inventions that changed the world All By KERRY GOLD and JOHN MACKIE The five major record companies will make their music available to consumers via the Internet as early as this summer. "The future will not look like the past in terms of how the public enjoys recorded music," says Brian Robertson of the Canadian Recording Industry Association, which represents the five major record labels, Bertelsmann (BMG), Sony, Warner Music, Universal Music and EMI. "Either through Napster or other alliances, certainly the five companies will have an online capability with an extensive repertoire by the middle of this See BIG RECORD Alt) INSIDE 1 have not succeeded in reviving the flame' UNIQUE PITCH FOR SUITE DEAL Apartment building owner tells Pete McMartin he wants to sell 'before he croaks' bi Bouchard exits, leaves divided party By SEAN GORDON Bouchard's legacy A5 Editorial A14 Barbara YaffeA14 v' Risk of evening showers FUI.LRrK)UT,A2 canada.com $1.25 RUTAIL $1.35 COIN BOX QUEBEC Premier Lucien Bouchard bid an emotional adieu to political life Thursday, citing his failure to achieve sovereignty and Quebecers' apathy toward his party's option as the principal reasons for his departure. After 13 years in politics, Eouchard officially tendered his resignation, admitting his best efforts simply weren't enough to rally Quebecers behind the idea of separating from Canada. "I accept the responsibility that befalls me for not having succeeded in reviving the flame and sensitizing our fellow citizens to the gravity of the situation.

I draw the conclusions that one must," he said with chagrin. And so it was that five years after being sworn in as Quebec's 32nd premier, Bouchard returned to the National Assembly's ornate Red Room for his valedictory address. "Quebecers remained surprisingly impassive in the face of federal offensives like the social union, the millennium scholarships, the university research chairs and the adoption of C-20, which seeks nothing less than to See BOUCHARD A6 At Home Horoscope C9 Births Deaths B6 Insight AB Bridge C4 Ann Landers E6 Paula Brook B3 Letters AW Business F6 Gary Mason Fl Classified C15 Pete McMartin Bl ComicsKids E7 Movies D2 Crossword Vaughn Palmer A14 C2, C5.C12 Fl Editorials AM Theatre D6 Entertainment Dl Wheels CI Ferry Schedule A2 Barbara Yafle A14 0 DIDIIR DEBUSSCHEREREUTERS MINIMUM SIDIi UIWKK MAINLAND oin Quebec Premier Lucien Bouchard wipes away tears as he prepares to give his resignation speech In Quebec City Thursday. i Good drivers deserve rewards. Safe drivers, such as our RoadStar and RoadStar Gold customers, are eligible to save even more than 40.

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