The San Francisco Examiner from San Francisco, California • 22

August 4, 1 974 Page 22 Section A btrtt S. F. Sunday Examiner Chronicle HEALTH FiNM W1HCC save! Safer heart transplants Don't Miss This Last Opportunity for Drastic Savings in Women's Shoes. A jugular forecast of rejection MADEMOISELLE Reg. 20.00 to 24.00 NOW 12 PRICE SELBY Reg.

27.00 to 38.00 NOW 12 PRICE air step Reg. 19.00 to 27.00 NOW Vi PRICE -fiSj IF X'A lv 1 pie say, fully 48 hours before it is seen in an electrocai-diogram. This means that doctors don't have to make desperate moves such as loading their transplant patients with dangerous drugs to fight rejection. These drugs often cripple the body's defense mechanism, opening the way for dangerous infections. Stanford heart specialists are even using the bioptome on outpatients.

"They get up and go straight home afterwards," said Dr. Alan Rider. He said the biopsy technique permitted doctors to study the earliest changes in the course of heart disease and live. "Previously, we only knew what heart tissue looked like after a patient died." As for heart transplantation, Stanford is the only medical center in the world still regularly doing it. Of the 73 individuals who have received a new heart here, 24 are still alive the longest more than five years now.

Medicine recognizes this as an incredible By Norman Melnick Examiner Science Writer STANFORD Stanford surgeons are using an amazing clipper that they thread through the jugular vein to snip off a small section of the heart. Doing this, they can predict a rejection episode in heart transplant patients much in advance of it happening. They are also learning a good deal about the mysteries of heart disease. The technique, started in August, 1972, is done almost routinely every day now. It takes only 20 minutes; there's no recuperation period afterward.

Dr. Norman Shumway, the internationally famous heart surgeon here, credits the instrument, called a bioptome, with substantially improving the survival chances of patients with new hearts. Ironically, the Japanese inventors of the device have never used it for heart transplant studies. "mmmimm DR. PHILIP CAVES HOLDS A BIOPTOME He helped to develop newer version HANDBAGS Reg.

12.00 to 30.00 NOW Vi PRICE ZAZZ Reg. 15.00 to 22.00 NOW 12 PRICE COVER GIRL Reg. 18.00 to 19.00 NOW Vi PRICE manipulate the clipper in the heart. As doctors watch on a fluoroscope. they pluck out a small portion of the heart for microscopic study.

heart surgeon who is the co-inventor of the bioptome, is quoted in Medical Tribune as saying: "I am very glad, as if I see a happy daughter after marriage, knowing that is Lr They do not do heart transplants. Dr. S'ouji Konno, a Tokyo sommer and kaufmann Stonestown (S.F.) San Bruno Hillsdale Stanford Concord (Sun Valley) Eastridge, Almaden, Valley Fair (San Jose) Hayward Santa Rosa Sacramento (Citrus Heights) Fresno Wherever else heart transplants have been tried, the record has been and continues to be a poor one. "People ask us why we continue to do transplants," said Spyros Andreopoulos, public relations chief of the medical center here. "The answer is very simple: Our track record is very good." Until the bioptome, there was no safe and simple method for taking a biopsy of the heart.

Doctors wanted one so that they could see with their own eyes live tissue from a new or diseased heart. Stanford surgeons have now examined nearly 300 of these biopsies. (our) bioptome (has been) helpful for the studies by Professor Shumway." The Japanese sent Shumway two bioptomes. Difficult to manipulate, their instrument has been succeeded by a shorter, more flexible model developed by Werner P. Schulz, a Burlingame engineer, and Dr.

Philip K. Caves, a surgeon who recently returned to the University of Edinburgh in Scotland. The bioptome consists essentially of a piece of wire with an expensive clipper at the end. First a tiny hole is made in the jugular vein in the neck. Then a catheter or plastic tube is inserted and passed on to the right ventricle of the heart.

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Capt. Ludlow is in charge of the San Francisco Police crime prevention detail. "We're getting a substantial improvement in survival," Shumway said, "and it looks as though we've improved the rejection death record since we began to use the bioptome." Most transplant patients die because their bodies reject their new hearts. Clinical and electrocardiographic clues of the rejection process normally do not show up for several days even after an episode has begun. The bioptome detects rejection, the Stanford peo- ,1 ce me ooeiimp' eir office at Inside, the catheter carries a steel wire with a scissors-like attachment at one end (outside the body) to oi in Pyramid 600 Monteo mery street T'i 1 lit, i II CO TAKE A PONG HOME OR TO YOUR OFFICE.

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