The Boston Globe from Boston, Massachusetts • 12

A12 THE BOSTON GLOBE NATION TUESDAY, NOVEMBER 10, Firm touts experimental treatment for arthritis pain RKUTKKS Alexion Pharmaceuticals told a meeting of rheumatologists in Boston that just one dose of the experimental drug reduced pain in half the patients who got it. ly crippling, often destroying joints. It affects 2.5 million Americans, mostly women ages 20 to 60. Its cause is unknown, but when people suffer from rheumatoid arthritis, their immune systems seem to be mistakenly attacking tissue in their joints and certain organs. Alexion scientists tested 42 patients with mild to moderate rheumatoid arthritis, half of whom got one injection of 5G1.1 in varying doses.

They told a meeting of the American College of Rheumatology that six patients got the maximum dose, and half of them showed a significant reduction in pain, compared to just one of the 10 patients who got a placebo injection. This was a Phase I safety trial. The company said it is enrolling 200 people for a Phase II safety and efficacy trial. tients who got it The drug is a monoclonal antibody an engineered version of one of the players in the body's immune system. When injected, it homes in on its target, which in this case is a molecule called C5 complement Alexion hopes that by inactivating this molecule, it can reduce the inflammation associated with rheumatoid arthritis.

Rheumatoid arthritis is extreme WASHINGTON A single dose of an experimental new treatment for rheumatoid arthritis gave a few patients "significant" relief from pain, the company that makes the drug said yesterday. Alexion Pharmaceuticals told a meeting of rheumatologists in Boston that just one dose of its anti-inflammatory complement inhibitor 5G1.1 reduced pain in half the pa Political Briefs Mrs. Clinton advised to 'give up day job' ALBANY, N.Y. The head of New York's Democratic Party suggested yesterday that Hillary Rodham Clinton "give up her day job" and concentrate more on her Senate campaign. Judith Hope, the state Democratic chairwoman, was reacting to the political fallout from Clinton's trip to the Middle East, in which the first lady belatedly responded to charges against Israel by the wife of Palestinian leader Yasser Arafat Hope said yesterday that "there is an increasing awareness that there is an incompatibility" between being first lady and running a Senate campaign.

"Of course, you can't just quit that job, but somehow, some kind of mechanism needs to be found to enable her to be a candidate," Hope said. (AP) Bush's book details his Vietnam plans WED. W0V.17 PREVIEW DAY IS TUES, WOV-16 nnTTT noon A mm 4 i 40 Off 40 OFF PLU IV. 40 10 Off PLUS BUY 2 BRAS, GET 1 FREE ALL Warner's underwires, softcups, more. Reg.

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But Bush says the program was being phased out by that point and that he lacked enough flight hours to qualify for the war-zone assignment Bush has insisted that no family influence was used to get him a slot in the Guard in 1968, during the height of the Vietnam War. After qualifying as an F-102 fighter pilot, Bush said, he heard that several fellow pilots had participated in a program called "Palace Guard" that rotated National Guard pilots to Vietnam to relieve active-duty pilots. "A friend and fellow pilot, Fred Bradley, and I were interested in participating and we talked with Colonel Jerry Killian about it. He told us the program was being phased out, that a few more pilots would go, but that Fred and I had not logged enough flight hours to participate," Bush writes. (AP) Trump campaigns in little Havana' MIAMI Donald Trump took his exploratory Reform Party presidential bid to Miami yesterday, wowing hard-line Cuban exiles who admire the billionaire real estate mogul's opposition to their homeland's communist government Trump was met on the tarmac by leaders of the Cuban American National Foundation.

Trump toured a local museum in the city's "Little Havana" neighborhood and viewed an exhibition memorializing Cuban exiles who died during the April 1961 Bay of Pigs invasion of Cuba. Referring to those killed in the invasion, Trump won more applause by criticizing the government of President John F. Kennedy, saying they had died "all because of the fact you were let down by our country." (Reuters) N.H.'s older voters back McCain in poll CONCORD, N.H. Senator John McCain is drawing much of his support in New Hampshire from older voters, according to two recent polls of people who plan to vote Feb. 1 in the nation's first presidential primary for the 2000 election.

That could spell trouble for Texas Governor George W. Bush, the front-runner for the Republican presidential nomination. Bush is more popular with those under 45, but older people are more likely to vote. An American Research Group poll of 600 likely Republican primary voters last week showed McCain in a statistical tie with Bush for the first time, with Bush at 41 percent and McCain at 38 percent The margin of error was plus or minus 4 percentage points. Bush led by 30 percentage points among voters 18-24 and by 12 points in the 25-44 age group.

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