Sunday Gazette-Mail from Charleston, West Virginia on July 16, 1972 · Page 65
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July 16, 1972

Sunday Gazette-Mail from Charleston, West Virginia · Page 65

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Charleston, West Virginia
Issue Date:
Sunday, July 16, 1972
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Page 65
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Page 65 article text (OCR)

STA TE MA GAZINE, July 16,1972 tial black parent undergo genetic counseling. Doctors suggest that sickle cell blood tests (which will diagnose trait as well as sickle cell anemia) be a part of routine pediatric examinations for all black children. The decision of parents with sickle cell trait to have children depends on the parents' phychological attitude toward taking a chance on having a child whose life expectancy is, at most. 45. These parents must ask themselves if they are strong enough to survive the psychological torture of watching their child writhe in agony during crisis. In rare cases, people with sickle cell trait may discover their condition. They may have a decreased ability to withstand certain physical stresses. Some people with sickle cell trait cannot long endure situations of decreased oxygen concentration. Physical exertion on the athletic field may cause a carrier of the trait to collapse without real cause. Normally, however, the trait will go undetected without specific clinical tests. The person with sickle cell anemia, on the other hand, will become painfully aware of his condition because of frequent crises during childhood. If this person survives childhood, adolescence usually brings a lessening frequency of sickle ceil crises. Treatments, to this date, have met with varying degrees of success. The ususal treatment follows the rule of common sense -place the patient in an atmosphere of concentrated oxygen and transfuse him with normal blood. In late 1970, a Michigan pathologist reported that urea, a normal constituent of urine, was an effective drug in the treatment of sickling. This man, Dr. Robert M. iValbandian, discovered that urea prevented crystaliza- tion of sickle hemoglobin. After extensive testing, urea was found to be somewhat less than safe. When treated with injections of large amounts of this chemical, experimental patients often suffered dehydration, drowsiness, and shrinkage of the brain. This April, however, researchers from Rockefeller University, headed by Dr. Anthony Cerami, expressed the opinion that it was not the urea that prevented sickle hemoglobin crystallization. Cerami reported that cyanate, a chemical component of urea solutions, might be the sought-after drug. Upon experimentation with this drug, Cerami and his researchers determined that cyanate inhibited sickling more effectively than urea. Their experiments. Cerami reported, indicated that cyanate, taken orally, increased the life span of red blood cells afflicted by sickling hemoglobin. The life span of a sickle red blood cell is about 30 to 40 days; a normal red cell lives 120 days in the human circulation. This has led the researchers to conclude that cyanate reduces the destruction of re^ -ells in patients with sickle cell anemia. Further testing of cyanate is being conducted, but there is now some hope that sickle cell anemia will soon have an effective adversary in the form of cyanate capsules. Medical researchers envision a day when cyanate, or a close chemical relative, can be used as an effective oral treatment for sickle cell disease. The "cure" for sickle cell anemia may well lie in genetic surgery to correct the mutation of genes that cause the trait to be inherited. The procedure would entail replacement of the defective genes within the egg and sperm of sickle cell trait carriers. This technique is in the future. For now, preventive medicine offers diagnosis of sickle cell trait and gentic counseling for potential parents. The chains of bondage known as sickle cell disease, the "black man's plague," must soon be broken. Through the accelerated efforts of medical researchers and the support and understanding of the American public, children like Tina Costa will one day be free. °"""""""''' tilt stroller delicately light as silk in fluid jersey of nylon 20.00 The Stroller makes it just the way you like it, with easy to step into button front convertible collar, pleated all around skirt, tailored print and workmanship to match. The jersey is a premium nylon that washes easily by hand or machine, drips dry, rarely needs the touch of an iron. Navy with Green or Black with Red. Sizes 10 to 20 and 12'A t o 2 4 ' / 2 . DAYTIME DRESSES--Street Floor Stone and Thomas, Charleston, W. Va. 25326 7/16/72 Please send me the Shelton Stroller. I have enclosed 60 : W. Va. State Sales Tax. Total 20.60 Ouon. Ut Color ' 2nd Color Sine Price Name Address City ·. State Zip Charge Q Check [J Money Order [] New Account Q If New Account Please Include Correct Credit Information. . r CHARLESTON, W. VA. :im

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