Honolulu Star-Bulletin from Honolulu, Hawaii • 1

SMdemly, a vaccine for AHDS geems possible By Ronald Kotulak Chicago Tribune For the first time since the AIDS to protect the body against the virus. "Before, the main issue was, 'Is an AIDS vaccine Koff said. "Now we have the first preliminary evidence that a vaccine is feasible, and we should have the convincing evidence within the next 18 months." Experimental vaccines are being tested on people already infected with the AIDS virus to determine if they could develop any kind of immune response. These vaccines could be generally available within the next few years, Koff said. Vaccines to protect infection-free people in the general population would take longer to develop because of the need to rule out any possibili But new preliminary findings indicate researchers have found approaches that can solve problems once considered insurmountable, said Dr.

Wayne Koff, chief of the AIDS vaccine research and development branch at the National Institute of Allergy and Infectious Diseases. The main difficulties researchers believe they can overcome are: The AIDS virus' ability to constantly mutate, thereby constantly changing the vaccine's target. Its skill at evading a major part of the immune system by hiding in the system's cells. Its preference for destroying the very immune system that is supposed ty that a vaccine might accidentally cause AIDS. 'Thus, they may not be generally available for six to seven years, he said.

The National Institutes of Health has given AIDS vaccine research a high priority because the development of new drugs to combat the disease has been disappointing. Only one drug, AZT, has been approved, and, although it prolongs life, it produces serious side-effects and is extremely expensive. The federal Centers for Disease Control in Atlanta estimates that more than 1 million Americans have been infected with the AIDS virus, which is transmitted primarily through sexual activity and by the sharing of contaminated needles among intravenous drug users. Nearly 130,000 people have been diagnosed as having AIDS and more than 78,000 have died, according to the centers. The World Health Organization estimates that as many as 300,000 people around the world may have died from AIDS.

At least nine different experimental AIDS vaccines are undergoing early trials in people to determine their safety. Further testing is necessary to find out if they are capable of building immunity against the virus. Outbreak began in the early 1980s, key government scientists are expressing confidence that it may be possible to develop AIDS vaccines that pould stop the deadly epidemic in its tracks. I Untl recently researchers working to develop vaccines were unsure that an effective one would ever be possible. The human immunodeficiency villus (HIV) that causes AIDS does not follow, the rules that govern other such as polio, for which life-saving vaccines have been developed.

tar-Bulletin Advertiser -n. A Aloha! XJta WORLD As Kalapana remembers better days 1 4 Ceausescus worked for CIA For 1 0 years, the CIA secretly bought advanced Soviet military technology from the family of Romanian dictator Ceausescu PageA31 4'. -if, HAWAII Will Fasi run? The Honolulu mayor says he is running for governor despite what the GOP's state chairman says Page A3 Advertiser photo by Carl Viti By Jan TenBruggencate Advertiser Kauai Bureau KALAPANA, Hawaii A curious mix of tension and resignation blended with the clouds of steam and burning asphalt at the edge of Kalapana yesterday. The village remained isolated, cut through the middle by a lava flow that spread in many directions yesterday. The center of attention was the node of the flow nearest the sea.

It filled low places and pushed along Beach Road, burning vegetation, boiling away ponds, cutting down utility poles and tall trees. Civil Defense administrator Harry Kim said he expected the lava to build up behind the Kalapana black sand dunes overnight and push into the sea sometime today. Last night, Gov. John Waihee signed a letter asking President Bush to declare a federal disaster for portions of the Big Island's Puna District, ravaged by lava from the current Kilauea Volcano eruption, which began in January 1983. Waihee is requesting public and private disaster assistance programs be offered to residents of Royal Gardens, Pacific Paradise Ocean Front Estates, Kapaahu, Keone, Kalapana Gardens and Kalapana.

Waihee estimated that damage from the Kilauea eruption so far totals $61 million, $46 million of that to private property. His request is being carried to Washington, D.C., by federal emergency management officials who inspected the damage on the Big Island last week. A response is expected this week, Waihee's office said. As he was signing the request, workers were preparing to move the Civil Defense command post from Harry K. Brown Park, whose boundary was penetrated by the lava late yesterday.

The park was as close as people could get to the old heart of Kalapa-. na. Gusty trade winds blew the smoke, steam and acrid fumes away from the park, but the smell of the flow See Kalapana, Page A8 FOCUS The lava had advanced to the edge of the shore and Harry K. Brown Park, lower left, by yesterday afternoon. Some analysts predict crash of 'crazy' Japan land prices Quitting on Quayle Republicans seem about to embark on a political game of musical chairs PageBI TRAVEL Space tourism There's lots to see in Florida, but why not plan a trip around a Cape Canaveral blastoff? PageEl days.

Many experts believe that U.S. trade pressure, along with Japan's high interest rates, falling stock prices and a change in psychology, could end the era of other-worldly land prices here. Prices in Osaka already are slipping, according to the real-estate industry. The cost of golf club memberships, traded like stocks and symbolizing Japan's stupefying land prices, have been slipping, too. Membership at one prestigious club near Tokyo declined from $1.3 million in mid-March to only $1.1 million two weeks later.

A crash would seem to answer the By Fred Hiatt Washington Post Service TOKYO Japan's stratospheric land prices are heading for a crash, says Kenichi Ohmae, best-selling author and management consultant. And that, he adds, would be "wonderful," since it would put Japan's economy into balance with the world. "But unfortunately," Ohmae said, "since this economy is intertwined with the rest of the world, the rest of the world will go under, too." While most government officials and many experts say a crash is unlikely, Ohmae is far from alone these prayers of many Japanese, who for years have bemoaned the ruinous consequences of living on the world's most expensive soil. But now that some experts forecast a decline, they are not so sure they want their prayers answered. "If government intervention is too effective, we can't deny the possibility that it could create a world depression," said Keiichi Tanaka, a land expert at Nihon University who sits on a prime minister's advisory council on reducing land prices.

"We have to slowly, slowly let See Japan, Page A6 WEATHER ft TONIGHT TODAY Brief morning showers, sunny this afternoon, high in mid-80s, gusty trades 15-30 mph, a few showers tonight Isie, Mainland details, Page A2 The Honolulu Advertiser produces the main news, Sports, Focus, Money. Travel and Health Science sections of the Sunday paper. The Star-Bulletin produces the Today and Home sections. Hawaii Newspaper Agency produces TV Week and Dining Out. Will the Rumblings from the barracks are getting louder and more ominous Prokhanov, a favorite author of the military establishment, in a sensational January manifesto in the nationalist weekly Literaturnaya Rossiya.

"The paralysis of the general-officer ranks and the reduction of the enlisted men and junior officers to a state of distraction are turning the army into a motionless, demoralized mass and depriving it of its basic defensive functions." Prokhanov declared that "the Soviet Union is weaker than ever before" and that "the blame for the failure of this five-year-long policy lies with the liberals," that is, Gorbachev. The apocalyptic tone of such writing lends credence to the widespread notion that part of the armed forces leadership may become desperate enough to consider a military coup. Most analysts believe, however, that no armed junta could hold power for long and that a coup attempt is therefore unlikely in the foreseeable future. By Scott Shane Baltimore Sun MOSCOW The Soviet military leadership, which initially backed perestroika as the price for a stronger economy, is growing deeply disillusioned with President Mikhail Gorbachev's reforms as it sees its budget shrink, its problems multiply and the Soviet's strategic position erode. While the top brass still professes overall support for Gorbachev's policies, officials from Defense Minister Dmitry Yazov on down are becoming publicly critical, particularly in publications intended for a military audience, of the effects of reform.

At the same time, they have entered an open alliance with right-wing Russian nationalist writers, who are freer to proclaim that perestroika is producing the demoralization of the Soviet army and the disintegration of the Soviet Union. "The army today is being destroyed like so many columns of soldiers in THE INDEX 24 sections, 384 pages Arts F10 Books F8.9 Classified ads H7-54 Crossword puzzle F8 Editorials B2 Entertainment F4-6, F12, F14, F15 Focus section B1-3 Health Science PI -3 Home section H1-6 Horoscope F11 Money section B4-8 Obituaries A36 People column A2 Restaurants Dining Out Sports section C1-12 TV schedules TV Week Today section F1-16 Travel section E1-10 AP photo Mikhail Gorbachev socializes with Soviet generals yesterday at an arts and entertainment festival sponsored by the Communist Party newspaper Pravda. .1 3: See Gorbachev, Page A17 an Afghan regime, wrote Alexander.