The Salina Journal from Salina, Kansas on April 22, 2001 · Page 70
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The Salina Journal from Salina, Kansas · Page 70

Salina, Kansas
Issue Date:
Sunday, April 22, 2001
Page 70
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Rx only PATIENT INFORMATION GLUCOPHAGE® (metformin hydrochloride tablets) and GLUCOPHAGE® XR (metformin hydrochloride extended-release tablets) Read this information carefully before you start taking this medicine and each time you refill your prescription. There may be new information. This Information does not take the place of your doctor's advice. Ask your doctor or pharmacist if you do not understand some of this information or If you want to know more about this medicine. What are GLUCOPHAGE and GLUCOPHAQE XR? GLUCOPHAQE and GLUCOPHAGE XR are used to treat type 2 diabetes. This Is also known as non-insulln-dependent diabetes mellitus. People with type 2 diabetes are not able to make enough Insulin or respond normally to the Insulin their bodies make. When this happens, sugar (glucose) builds up In the blood. This can lead to serious medical problems Including kidney damage, amputations, and blindness. Diabetes Is also closely linked to heart disease. The main goal of treating diabetes Is to lower your blood sugar to a normal level. High blood sugar can be lowered by diet and exercise, by a number of medicines taken by mouth, and by Insulin shots. Before you take GLUCOPHAQE or GLUCOPHAGE XR, fry to control your diabetes by exercise and weight loss. While you take your diabetes medicine, continue to exercise and follow the diet advised for your diabetes. No matter what your recommended diabetes management plan Is, studies have shown that maintaining good blood sugar control can prevent or delay complications of diabetes, such as blindness. GLUCOPHAGE and GLUCOPHAGE XR have the same active Ingredient. However, GLUCOPHAGE XR works longer in your body Both of these medicines help control your blood sugar In a number of ways. These Include helping your body respond better to the Insulin It makes naturally, decreasing the amount of sugar your liver makes, and decreasing the amount of sugar your Intestines absorb. GLUCOPHAGE and GLUCOPHAGE XR do not cause your body to make more insulin. Because of this, when taken alone, they rarely cause hypoglycemia (low blood sugar), and usually do not cause weight gain. However, when they are taken with a sulfonylurea or with Insulin, hypoglycemia is more likely to occur, as Is weight gain. WARNING: A small number of people who have taken GLUCOPHAGE have developed a serious condition called lactic acidosis. Lactic acidosis is caused by a buildup of lactic acid In the blood. This happens more often In people with kidney problems. Most people with kidney problems should not take GLUCOPHAGE or GLUCOPHAQE XR. (See "What are tha side effects of GLUCOPHAGE and GLUCOPHAGE XR?") Who should not take GLUCOPHAGE or GLUCOPHAGE XR? Some conditions Increase your chance of getting lactic acidosis, or cause other problems If you take either of these medicines. Most of the conditions listed below can increase your chance of getting lactic acidosis. Do not take GLUCOPHAGE or GLUCOPHAGE XR if you: • have kidney problems • have liver problems • have heart failure that is treated with medicines, such as Lanoxin* (dlgoxin) or Lasix* (furosemide) • drink a lot of alcohol. This means you binge drink for short periods or drink all the time • are seriously dehydrated (have lost a lot of water from your body) • are going to have an x-ray procedure with injection of dyes (contrast agents) • are going to have surgery • develop a serious condition, such as heart attack, severe Infection, or a stroke • are 80 years or older and you have NOT had your kidney function tested Tell your doctor If you are pregnant or plan to become pregnant. GLUCOPHAGE and GLUCOPHAGE XR may not be right for you. Talk with your doctor about your choices. You should also discuss your choices with your doctor If you are nursing a child. Can GLUCOPHAGE or GLUCOPHAGE XR be used In children? GLUCOPHAGE has been shown to effectively lower glucose levels In children (ages 10 to 16 years) with type 2 diabetes. GLUCOPHAGE has not been studied In children younger than 10 years old, GLUCOPHAGE has not been studied In combination with other oral glucose-control medicines or insulin in children. If you have any questions about the use of GLUCOPHAGE In children, talk with your doctor or other healthcare provider. GLUCOPHAGE XR has not been studied in children. How should I take GLUCOPHAGE or GLUCOPHAGE XR? Your doctor will tell you how much medicine to take and when to take It. You will probably start out with a low dose of the medicine. Your doctor may slowly Increase your dose until your blood sugar Is better controlled. You should take GLUCOPHAGE or GLUCOPHAGE XR with meals. Your doctor may have you take other medicines along with GLUCOPHAGE or GLUCOPHAGE XR to control your blood sugar. These medicines may Include Insulin shots. Taking GLUCOPHAGE or GLUCOPHAGE XR with Insulin may help you tsetter control your blood sugar while reducing the Insulin dose. Continue your exercise and diet program and test your blood sugar regulariy while taking GLUCOPHAGE or GLUCOPHAGE XR. Your doctor will monitor your diabetes and may periorm blood tests on you from time to time to make sure your kidneys and your liver are functioning normally. There is no evidence that GLUCOPHAGE or GLUCOPHAGE XR causes harm to the liver or kidneys. Tell your doctor If you • have an illness that causes severe vomiting, dian-hea or fever, or if you drink a much lower amount of liquid than normal. These conditions can lead to severe dehydration floss of water In your body). You may need to stop taking GLUCOPHAGE or GLUCOPHAGE XR for a short time. • plan to have surgery or an x-ray procedure with injection of dye (contrast agent). You may need to stop taking GLUCOPHAQE (metformin hydrochloride tablets) or GLUCOPHAGE XR (metformin hydrochloride extended-release tablets) for a short time. • start to take other medicines or change how you take a medicine. GLUCOPHAGE and GLUCOPHAGE XR can affect how well other drugs work, and some drugs can affect how well GLUCOPHAGE and GLUCOPHAGE XR work. Some medicines may cause high blood sugar. What should I avoid while taking GLUCOPHAGE or GLUCOPHAGE XR? Do not drink a lot of alcoholic drinks while taking GLUCOPHAGE or GLUCOPHAGE XR. This means you should not binge drink for short periods, and you should not drink a lot of alcohol on a regular basis. Alcohol can increase the chance of getting lactic acidosis. What are the side effects of GLUCOPHAQE and GLUCOPHAGE XR? Lactic Acidosis. In rare cases, GLUCOPHAGE and GLUCOPHAQE XR can cause a serious side effect called lactic acidosis. This Is caused by a buildup of lactic acid in your blood. This build-up can cause serious damage. Lactic acidosis caused by GLUCOPHAGE (metformin hydrochloride tablets) and GLUCOPHAGE XR (metformin hydrochloride extended-release tablets) is rare and has occurred mostly In people whose kidneys were not working normally. Lactic acidosis has been reported In about one In 33,000 patients taking GLUCOPHAGE over the course of a year. Although rare. If lactic acidosis does occur. It can be fatal In up to half the people who develop it. It Is also Important for your liver to be working normally when you take GLUCOPHAGE or GLUCOPHAGE XR. Your liver helps remove lactic acid from your blood. Make sure you tell your doctor before you use GLUCOPHAGE or GLUCOPHAGE XR If you have kidney or liver problems. You should also stop using GLUCOPHAGE or GLUCOPHAGE XR and call your doctor right away If you have signs of lactic acidosis. Lactic acidosis Is a medical emergency that must be treated in a hospital. Signs of lactic acidosis are: • feeling very weak, tired, or uncomfortable • unusual muscle pain • trouble breathing « unusual or unexpected stomach discomfort • feeling cold • feeling dizzy or lightheaded • suddenly developing a slow or Irregular heartbeat If your medical condition suddenly changes, stop taking GLUCOPHAGE or GLUCOPHAGE XR and call your doctor right away. This may be a sign of lactic acidosis or another serious side effect. Other S/'de Effects. Common side effects of GLUCOPHAGE and GLUCOPHAGE XR Include dIan-hea, nausea, and upset stomach. These side effects generally go away after you take the medicine for a while. Taking your medicine with meals can help reduce these side effects. Tell your doctor If the side effects bother you a lot, last for more than a few weeks, come back after they've gone away, or start later In therapy. You may need a lower dose or need to stop taking the medicine for a short period or for good. About 3 out of every 100 people who take GLUCOPHAGE or GLUCOPHAGE XR have an unpleasant metallic taste when they start taking the medicine. It lasts for a short time, GLUCOPHAGE and GLUCOPHAGE XR rarely cause hypoglycemia (low blood sugar) by themselves. However, hypoglycemia can happen If you do not eat enough, If you drink alcohol, or If you take other medicines to lower blood sugar. General advice about prescription medicines If you have questions or problems, talk with your doctor or other healthcare provider. You can ask your doctor or phamnaclst for the Information about GLUCOPHAQE and GLUCOPHAGE XR that Is written for health care professionals. Medicines are sometimes prescribed for purposes other than those listed in a patient Information leaflet. Do not use GLUCOPHAGE or GLUCOPHAGE XR for a condition for which It was not prescribed. Do not share your medicine with other people. GLUCOPHAGE' Is a registered trademark of LIPHA s.a. Licensed to Bristol- Myers Squibb Company. I Bristol-Myers Squibb Company Princeton, NJ 08543 U.S.A. Make—s JMt.? Difference ^ Day Awards Michael AndrettI and California kids: a day at the races 6060D1M-10 1125493A1 F5-B057B-01-01 Revised January 2001 Encore! For continued giving, each of these 5 past national honorees receives a 2001 Encore Award of $2,000, funded by the Gannett Foundation. • San Bernardino, Calif. Herculean Mal<eA Difference Day efforts since 1995,3 1997 national award, and even greater heights last October, when 156,000 volunteers helped 18,900 needy in 10 projects.Their feats are organized by San Bernardino County and Norcal/San Bernardino. • Maxwell Air Force Base, Montgomery, Ala. The 42nd Air Base Wing received a 2000 award for fixing up an abandoned 20-room estate for Shepherd's Staff Ministry, a non-profit group that has housed 43 foster children. In October, the wing tackled another abandoned house, this one to be used as a shelter for victims of domestic violence. As of Feb. 23,612 service members had volunteered 2,662 hours and raised $6,568.20 for the endeavor. ^ Miami University of Ohio and the University of Virginia. Twin brothers challenged their colleges to do the most good; the rivalry received a 1999 national award. The twins graduated, leaving legacies: In October, Ohio participation rose to 2,000; participation in Virginia soared to 5,000 in 23 projects. • Pottsville, Pa. When 9,700 people tackled 145 projects, helping 5,000 of their neediest neighbors, they merited a 2000 national award. Last October, volunteers topped 10,000, many of them children. • Racine,Wis. 8,600 volunteers received a 1999 national award; in October, volunteers swelled to 14,000. Among them: 25 inmates at Racine Correctional Institution who raised $400 for literacy programs by doing laps around their yard, ca 14 USA WEEKEND • April 20-22,2001

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