The Salina Journal from Salina, Kansas on April 20, 2001 · Page 10
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The Salina Journal from Salina, Kansas · Page 10

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Salina, Kansas
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Friday, April 20, 2001
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Page 10
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||,^fl1D FRIDAY. APRIL 20, 2001 HEALTH THE SALINA JOURNAL • MEDICAL LANDMARKS Mechanical heart breakthrough imminent Five U.S. hospitals £)K'd to transplant «elf-contained devices ^By PAUL RECER '7 /16 Associated Press, WASHINGTON — An American on the brink of death soon will receive the first self-con- -tained, mechanical total heart -replacement in a landmark "surgery experts hope will lead •to new hope for patients with failing hearts. Heart surgery teams at five hospitals are trained and poised to remove a diseased natural heart and install in its place an electric-powered pump designed to fit inside the chest with no wires or tubes sticking through the skin. Officials of Abiomed Inc., •which developed the mechani- .cal heart, said Wednesday the Jirst surgery, no later than June 30, would proceed without prior announcement and the patient's identity may not be released. Results of the procedure, they said, would not be made known to the public for at least 30 days. David M. Lederman, presi- Artificial liver on i the horizon 1 Scientists discover ; Ijver cells thrive on special silicon chips ;'^y ANDREW BRIDGES , The Associated Press '/ SAN DIEGO — Scientists . have coaxed liver cells into thriving on a specially machined silicon chip, a melding of biology and technology that . could lead to the creation of an artificial liver device that , would eliminate the need for . transplants. , The team at the University of Califomia-San Diego says it .has succeeded in keeping rat liver cells alive and fully functional on the special chips for at least two weeks. In prototypical artificial liver devices now being clinically tested, liver cells — which can be notori- . ously finicky — often survive only hours or days. For the experiment, the team used silicon wafers — the same blanks used .to make computer chips — etched with t-iny wells no wider than a human hair that snugly house the individual cells. The rest of ^, the wafer is riddled with pores . of various sizes that allow nutrients and chemicals to flow through the chip but blocks . the larger bacteria and viruses. "This is a very fundamental kind of a project: What can we • do to make cells happy and to ; keep them growing?" said , 'Michael J. Sailor, a professor , ;pf chemistry and biochemistry at the university. . The team presented the chip 'at the recent annual meeting of the American Chemical Soci, ety in San Diego. The team foresees a day -vyhen stacks of the chips, per- liaps a square yard's worth, could be combined to form an artificial liver that would : cleanse the body's blood of tox- . ins. As many as 300,000 liver . cells can live on a patch of the special chips just 0.16 square- .inch in area. The chips have not yet been harnessed to substitute the blood-cleansing role of a real liver. Dr. Achilles Demetriou, .: ehairman of the department of .surgery at Cedars-Sinai Med- -ical Center in Los Angeles, , said environment will put the chips to the test. .'••i. "We can now with vei'y cheap, low-tech systems, keep •cells alive in culture for weeks. .The issue with any new device is what happens when those cells are exposed to toxic plasma, which is similar to what you see in a patient with severe liver failure," said Demetriou, who helped developed an artificial liver that uses pig cells. If such a stacked-chip system could be devised, it could keep alive patients suffering from liver failure while they : await a transplanted organ — •jjr longer to allow their livers ;-tb naturally regenerate. SPA SERVICE 825-88S8 SPA SERVICE Hsmi \:Niriill dent and chief executive officer of Danvers, Mass.-based Abiomed, said the company received Food and Drug Administration approval to perform at least five human trials with the artificial heart, known as Abio- Cor. If the experiments are successful, more patients could be added to the trial later, he said. The patients selected for the trial must be suffering from a chronic, progressive heart disease expected to result in death within 30 days. The goal of the experimental trials with the artificial heart, said Lederman, is to "double the life span of these patients," to 60 days. "Every patient will probably die on the AbioCor," he said. "We need to understand that, with this new technology, we may have failures." Lederman said a second goal is to evaluate how the unattached, mobile mechanical heart affects the quality of life of those patients, most of whom are so ill that they cannot walk or perform the daily routine of life, such as getting dressed. Less advanced mechanical hearts have been implanted in Mechanical heart For some patients with falling heartj. dodors will soon Implant a mechanical hsarl that has no wire or tube outside the body Hesf archpra hope patients will live at least 60 dayb Aith the experimental device, longer With later models. Here's how it worl<s: O An external battery pack | transmits power to a coil, wireless transfer system. \ O An internal coil receives the power and sends it to the controller and backup, rechargeable battery. O The controller regulates the heart rate and speeds or slows its pace as needed. Wirples' transfi r sysl m Internal coll RochargciUe battery SOURCE: Abiomed Inc. patients in the past, but they were all attached to outside electrical or pumping power consoles. Some such devices are still used as a "bridge," keeping patients alive until a heart transplant is available. There also are devices that take over only part of the heart's job, the left ventricle. One such device, developed at the University of Pennsylvania, is self- contained within the chest. It Emily Brannan/AP has been used on a few patients in Europe and one in the United States, according to Dr. Michael Acker of the University of Pennsylvania. Th'e AbioCor is the first me­ chanical'device designed to replace the entire heart that is totally self-contained within the chest and not connected to outside power or pumps, Lederman said. About 700,000 Americans an­ nually die of heart failure. About half die suddenly, with no chance for therapy Heart transplantation is the best hope for most of the others, but only about 2,000 organs are available each year, Lederman said. He estimated about 100,000 Americans annually could prolong their lives with a proven, reliable mechanical heart. The AbioCor device does not resemble a real heart, but looks more like what it is: a pump made of titanium and plastic with four protruding tubes that are connected to the body's cardiac vessels. There are internal mechanical valves that mimic the action of the natural heart's pump system. Power comes from a battery pack worn outside the body A coil sends power through the skin to an implanted coil that then carries the power to an implanted control package and* backup, short-term battery The external battery pack must be recharged every four hours, but the patient can wear a spare package. The internal battery is kept charged and can operate the heart for about 30 minutes without the external battery "This not only will extend life, but it also restores the quality of life for these patients," said Robert T.V. Kung, Abio- med's chief scientist. "Patients will be able to shower, change clothes and walk around." Sensors command the mechanical heart to pump faster when the body is exercising and muscles need more oxygen, Kung said. The pump, implanted in the chest, and its support devices, implanted in the abdominal cavity, weigh a total of 3 pounds. The external battery pack and monitor, worn on a belt, weigh about 4 pounds. Lederman said the complete heart replacement device costs about $75,000 and will cost another $175,000 for procedure expenses. Kung said the performance of the mechanical heart can be monitored constantly at a remote center. A low frequency radio signal is sent from the external monitor worn by the patient, picked up by a transmitter and relayed to a central computer that reads the pumping rate, temperature and general condition of the artificial heart. New Product and Showroom Updates At Orrs Furniture City, we are constantly striving to keep our inventory and showrooms on the cutting edge of fashion here in the midwest. With this in mind we have recently decided to update our main floor showroom which includes the Lane Gallery, Winners Only Gallery, casual wood dining area and our mattress department. This update will be both the products on the floor and the showrooms themselves. Consequently the decision has been made to immediately commence an inventory liquidation of all products in the following categories: all Lane recliners, motion sofas and loveseats, sleepers, Lane leather groups, motion sectionals, all Winners Only home office products, all casual wood dining and dinettes, all coordinating occasional table groups, curios, grandfather clocks and all bedding products. In addition to these main floor showroom products we are also liquidating Samuel Lawrence bedrooms. Riverside living rooms and a variety of Thomasville beclrooms and formal dinin REMODELING LI UIDATION Lane Velvet Recliner List $499 Mastercraft Leather Sofa List $2,800 Sale $888 Lane Reclining Sofa List$ 1,350 Sale $488 Oak 5 piece Dining Set List $599 Sale $277 Riverside Roll Top Desk List $630 Sale $248 Twin Size Mattress List $149 Sale $59 Open weekdays 10am to 8pm • Saturdays 10-5 • Sundays 1-5 Grandfather f Clock Cable and pulley weighis List $2,099 Sale $877 Curio 48x80 Sliding Front Door List $2,170 Sale $947 Thomasville Celebrity Bed Twin $198 set Full $228 set Queen $288 set King $398 set Lane Leather Recliner List $1,139 Sale $388 Lane Reclining Sectional List $3,636 Sale $1,488 3 Drawci Oak Fil Cabinet List $619 Sale $277 5 Shelf Lawyer's Bookcase List $1,129 Sale $488 7 Piece Oak Dining Set List $1,465 Sale $648 Lane Leather Sofa List $1,890 Sale $897 Thomasv lie Dresser, Mirror and Queen Bed List $2,995 Sale $1,488 LaCrosse Sofa List $1,134 Sale $425 Riverside Sofa List $828 Sale $396 Lane Reclining Loveseat List $1,440 Sale $488 Queene Anne Tables List $306 Sale $98 Cherry Rice Carved Bed Queen Size List $1,249 Sale $544 Lane Reel. Sectional List $3,312 Sale $1,398 i Twin, Full, Queen Sleeper Your Choice of size List $999 Sale $398 Thomasville Dresser, Mirror Chest, Queen Headboard List $3,895 Sale $1,588 Lane Reclining Sofa List $1,710 Sale $588 Grandfather Clock Cable Driven List $2,159 Sale $996 Lane Floral Sofa List $1,221 Sale $477 Cocktail Table or End Table List $720 Sale $298 Six Months No Payments and No Interest FinanGiiigAyailable ORR'S FURNITUBE CITY Phone Toll Free 518 Lincoln Ave. 1-888-557-5865 P.O. Box 23 email: orrs@kansas.net Downtown Clay Center with approved application Open Weeknights 'Til 8 p.m. Saturday 10-5 Sunday 1-5

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