The Philadelphia Inquirer from Philadelphia, Pennsylvania • Page D07

THE PHILADELPHIA INQUIRER www.philly.com D7 Monday, April 11, 2005 On the Soaps The last gasp of a child-killer Ask Dr. H. By Mitchell Hecht A double dose of Fosamax week should work as well as 70 mg twice a week, except that the once-a-week regimen will likely cause intolerable heartburn, a well-known side effect of Fosamax. Your high dose of Fosamax is not FDA-approved for osteoporosis. A more effective and tolerable treatment option might be Forteo parathyroid hormone injections daily.

While not indicated for folks with Pag-et's disease of the bone, it will do a better job strengthening your brittle osteoporotic bones. Ask your endocrinologist about it. KNIGHT RIDDER NEWS SERVICE Question: I have been taking Fosamax 70 milligrams twice a week instead of once weekly on the advice of my endocrinologist. My other doctors and my pharmacist have never heard of taking two 70mg Fosamax pills weekly. It does seem to give me a big problem with heartburn.

Can you steer me in the right direction? Answer: It's not unusual to take 140 mg weekly of Fosamax. The FDA-approved dosage for Fosamax in treating osteoporosis used to be 10 mg daily, but for convenience has been replaced with a once-weekly 70 mg tablet. Because of the way in which Fosamax acts on bone cells, 70 mg once a week works as well as 10 mg daily. Fosamax at a dosage of 140 mg (two 70 mg tablets) once a Mitchell Hecht is a physician in internal medicine. Send questions to: "Ask Dr.

Box 767787, Atlanta, Ga. 30076. Due to the large volume of mail, personal replies are not possible. By Seli Groves All My Children Jonathan forced Kendall to join Greenlee and Lily in the mine shaft and then contacted Ryan, but said nothing about his three hostages. Jamie told Babe about David's obsession with Dixie.

David, in the meantime, became fascinated by Di. As the World Turns To Lily's surprise, Keith came to her rescue. Carly saved the day after putting one over on Les. Jennifer pondered cutting her ties to Craig. Mike was on the receiving end of a bombshell from Barbara.

The Bold and the Beautiful Despite his pain at not having a child with Brooke, Nick reassured Bridget that he looked forward to having children with her. Brooke told Stephanie that she believed his words reflected lingering feelings for Brooke. In Venice, Amber got into the apartment with Ridge, who didn't know her, but told her that Morgan brought him to Venice. Days of Our Lives Chelsea was determined to get Patrick for herself. SamiStan got new orders from her "boss." Bonnie caught Abby and Chelsea at Alice's bar.

Mimi told Belle about her fight with Jan. John felt guilty about failing to find Philip. After sharing a romantic getaway, Bo and Hope returned to find Billie and Patrick in a compromising position. An angry Kate slapped Belle. Nancy had news for Brady.

General Hospital Sonny agreed to a court-ordered psychiatric evaluation, but warned Ric that he'd take Kristina away from Alexis. Carly had more visions of Michael. Rachel recalled being manipulated by AJ. Reese told Carly of her son's kidnapping and murder. Guiding Light Harley felt that the only way to save Gus was to break his heart.

Olivia begged Bill to forgive her, as she dug herself deeper into trouble. Dinah got carried away playing Cassie. Michelle and Danny took a new look at their future. One Life to Live Nora rejected Bo's plea not to wed Daniel. Jen asked Rex to leave the wedding before Riley saw him.

Jessica, as Tess, had a hard time keeping it together in front of Viki and Antonio. Dorian's warnings to Blair about Margaret's returning flooded Todd with memories and prevented him from being able to make love to Blair. Passions Ethan recalled Alistair's phone call and realized Fox might not be able to return within 72 hours to contest Whitney's putting her baby up for adoption. Alistair told Katherine that Martin had reunited with Pilar. Alistair then made advances to Katherine.

Gwen rushed to help, and Alistair turned on her, torturing her both physically and emotionally. The Young and the Restless Drucilla was caught in the middle as the battle between the Newmans heated up, putting Dru's new executive position in jeopardy. Jill persuaded Esther to help in her latest scheme to win back Katherine's favor. no longer required, it was easier for juries to find pharmaceutical companies liable," he wrote. Offit contends that fears of being sued have "driven companies away from making life-saving products like vaccines." Offit said his interest in writing about the Cutter incident was sparked by conversations over lunch with Neal Nathanson, a University of Pennsylvania virology specialist who 50 years ago was a public health doctor assigned to investigate polio cases associated with the vaccine.

Nathanson, in an interview, said he had just arrived at what is now called the Centers for Disease Control and Prevention (CDC), when he was appointed to head the new Polio Surveillance Unit. "I was the only body that was free," he recalled. "I had no training at all It was truly an on-the-job kind of thing." The government's investigation revealed that Cutter wasn't the only manufacturer with problems. Wyeth Laboratories, for one, also produced some faulty vaccine that was linked to at least 15 cases of paralysis and one death, Offit said. Nathanson, as part of his job, produced a report specifically on Wyeth.

But the report was never made public a decision he said was made by his superiors. All the companies quickly made improvements in manufacturing. The Cutter incident faded from the public's mind and confidence in the polio immunization program was restored. "Between 1955 and 1962, a total of 400 million doses of safe, inactivated polio vaccine were distributed in the United States," Offit wrote in the April 7 New England Journal of Medicine. "The incidence of polio decreased dramatically." Great Sex! CUTTER INCIDENT from Dl dent named after the California company that made the problematic doses which explores the vaccine's darker side and shows how medical advances often come with setbacks.

The polio case, in addition, triggered litigation that set the pattern for future medical lawsuits, which continue to frustrate innovation today, Offit said. He writes about the Cutter case in the current issue of the New England Journal of Medicine. Tomorrow scientists will mark the 50th anniversary of the announcement that the polio vaccine developed by Jonas Salk of the University of Pittsburgh had proven successful in a study involving 1.8 million children, and that routine vaccination of the nation's children could begin. "It's one of the great American stories of science and technology," said Howard Markel, a physician and medical historian at the University of Michigan, where 1,200 people jammed into an auditorium to hear the results. A nation gripped by fear embraced news that Salk's vaccine, made of killed polio virus, was "safe, effective and potent," according to the epidemiologist quoted at the original news conference.

There were well-ingrained images in the public's mind of healthy, happy children playing one minute, and then paralyzed and in an iron lung the next. "You could put your child to bed at night, and the child might complain of a sore throat, nothing much, and the next morning the child might say, 'Mommy, Daddy, I can't move my Markel said. Mary Jane Newman, 81, of Newtown Square, Delaware County, was raising two boys in Pittsburgh in the early 1950s and polio was one of her biggest worries. "We never let our kids go to the movies or swimming or anything" for fear of being exposed to the virus, Newman recalled last week. When a letter came home from school saying her boys could get the experimental Salk vaccine, "we were so afraid of polio, we decided we should let our children help out," she said.

But Offit offers a surprising look at how joy over the new vaccine was quickly tempered. Within two weeks of the vaccine's rollout, the government got word that five children in California had become paralyzed after getting vaccine made by Cutter Laboratories. Cutter vaccine was recalled, but not before 380,000 of the company's doses had been administered. An investigation traced the problem to two lots of vaccine, 120,000 doses in all, which contained live polio virus, Offit said. Formaldehyde used in the production process should have killed the virus, but didn't.

The nation's polio-immunization campaign was halted for about a week while the investigation was being done, but then quickly resumed. Today such a scandal would likely cause a vaccine's withdrawal and a company's demise, Offit said, but attitudes were different in the 1950s. "People were scared to death of polio and the fact was that, for the most part, there was faith in the polio program," Offit said. He said the Cutter incident led to new federal regulations for vaccine production. Offit said the Cutter incident also helped set the stage for the often contentious medical-legal climate that exists today.

A lawsuit filed by a family whose child was harmed by the vaccine resulted in a new type of verdict in which Cutter was found liable, or financially responsible, for problems caused by its product. But it was not found negligent in the production of the product resulting in the legal precedent of "liability without fault," Offit said. "Since proof of negligence was 1 Hour of Pleasure in 5 minutes Now available Fast Acting Medication, Works in Minutes Erectile Dysfunction Premature Ejaculation Penile Curvature Erections Thicker Longer liillllllllll ifclllllllMliRi Learning to Dance is Fun and Easy the Arthur Murray Way! Singles Couples Welcome. Call Today! Arthur Murray Franchised JSDance Studios NARBERTH 913 Montgomery ave (610) 668-8870 DAAI I on AfccT i ampaotcd awc Ciftt E. N0RRIT0N 2943 swede rd (610) 279-9626 Contact staff writer Susan FitzGerald at 215-854-2780 or sfitzgeraldphillynews.com.

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