Indiana Gazette from Indiana, Pennsylvania • 4

Page 4 Wednesday, December 19, 1990 tEfa (gatette Researchers aiming radiation at cancer fnr white and red cancer and one neuroblastoma patient have survived. The others died of reactions to the chemotherapy or radiation or of relapse, Bensinger said. He said he was unaware of similar experiments by other researchers. The treatment "has the potential to get rid of tumor cells and ultimately may be a better way to get rid of tumor cells in bone marrow," Bensinger said. The Hutchinson center is the world's largest cancer treatment center using bone marrow trans, plants.

It performs about 400 of them annually. Research using monoclonal anti-' bodies is also being conducted at the National Institutes of Health in Washington, the Dana-Farber Cancer Institute in Boston, Johns Hopkins in Baltimore and the Cancer Chemotherapy Center in Tokyo, among others. work of Dr. E. Donnall Thomas, who performed the first human bone marrow transplant in 1956 and was awarded the Nobel Prize this year.

Thomas is assistant director of clinical research programs at the Hutchinson center. The radiolabeling treatment was developed because some lymphoma and leukemia patients whose cancers were killed beyond detection using standard bone marrow transplants had recurrences. The patients in the immunotherapy trials have malignant diseases for which transplantation is the only cure. For lymphomas, radiolabeling has been used without additional radiation or chemotherapy, while for But even at lower doses, no sign of the cancer could be detected after treatment in most patients, Bernstein said. Three of the patients have had long-term remissions, while the rest are in treatment or have relapsed.

Five leukemia patients have been given the new treatment in clinical trials that began last year. It is too early to reach any conclusions for those patients, said Fred Apple-baum, another transplant program director. Another research project at the center is using monoclonal antibod-ies to sift healthy stem cells in bone marrow from cancerous cells in patients with solid tumor cancers that have spread widely. Stem cells leukemias it has been used in conjunction with the more standard transplant procedures. That involves removing a patient's bone marrow, administering massive full-body doses of radiation and chemotherapy sometimes greater than the amount given off by the Chernobyl nuclear accident and reinjecting the marrow.

Bone marrow is lulled by high doses of radiation. Over the past two years, 11 patients have been treated for lymphomas with monoclonal antibodies radiolabeled with as much as one-half curie of 1-131, a level of radiation that would be fatal if the injection was not followed by a marrow transplant. blood cells and platelets. White blood cells were incubates with monoclonal antibodies made in mice and goats. The resulting "sandwich" monoclonal antiooay binds to the normal stem cells when they are passed through a column, said researcher William Bensinger.

The technique allows the blood to be cleansed of any cancerous cells, which may not be killed by radiation and chemotherapy. The treated cells are reinjected to replace the patient's bone marrow. Nine patients with very advanced breast cancers and three with neuroblastomas (tumors that usually afflict children) have been treated using the technique. One breast MORE DAYS STOREWIDE 10 SUN WON lit 4 C0UNTD0W1 SALE FREE GIFT WRAP Remember, al you last-minute Santas, when you purchase your gifts at The Bon-Ton, we'll wrap Ihem In gala holiday paper and add a bow, and it's absolutely free! XJy By CARRIE FIG DOR Aftobatod Preu Writ.tr SEATTLE (AP A new cancer treatment using genetically engineered molecules that aim extremely high doses of radiation at cancerous tissue may double doctors' ability to destroy some cancers, researchers say. Scientists at the Fred Hutchinson Cancer Research Center are using the techniques to deliver the highest doses of radiation ever directed at human cancer tissue in an attempt toicure.

attaching radioisotopes to monoclonal antibodies and injecting them into patients, widespread cancers can be destroyed with massive amounts of radiation that otherwise uld be fatal -Antibodies are proteins formed by nobody's Immune system to fight flweign substances, or antigens. IJCinoclonal antibodies are geneti-adJJy- identical molecules, usually levlloped in mice, that can be targeted at cancer cells. Xhe Hutchinson radiolabeling research is unique in that the scientists Ire. using antibodies to which more radiation, in the form of radioisotopes, has been attached than those used by any other group. Si-Researchers are still testing to grid the highest level of radioisotopes that can be used, said Irwin Bernstein, a professor of pediatric $cology at the center and the niversity of Washington.

fr'We hope to deliver twice the imbunt of radiation, and thus be Qmce as efficient in destroying the egncer cells," said Rainer Storb, a program director in transplantation biology. The researchers believe the procedures will enable them to treat some advanced solid tumor cancers as well as leukemias and lymphomas. the research is being done in collaboration with the University of Washington and is supported by grants from the National Institutes of Health. The trials are an outgrowth of the Mary Christmas enjoys unusual moniker GALIVANTS FERRY, S.C. AP) Mary Christmas says it wouldn't be a merry Christmas without a little merriment about her holiday moniker.

"It's a good conversation piece and I never get tired of people laughing about my name," said the 38-year-old mother of three. Sometimes, however, her name can get her in a pickle. For example, phone conversations can became more than a bit twisted when she picks up at the Horry County Alcohol and Drug Abuse Commission. had several people hang up on me in the last week," Mrs. Christmas said.

''But once they find out my name really is Mary Christmas, they never forget it." Her 13-year-old daughter, also named Mary Christmas, also said the name is cause for unwanted attention. ''All my teachers call on me to do stuff for them because they can't remember anyone else's name," the eighth-grader complained. "One time a woman wouldn't cash my check. She refused to believe anyone could have the name Mary Christmas." Mrs. Christmas said.

Mary Christmas was not always Mary Christmas. She was Mary Alice Alien until 18 years ago when sahe married Kent Christmas, who works at a local car dealership. "At first, I never really thought about it because mv friends usually called me 'Mary she said. other people started calling mc Mary Christmas and it stuck. No one ever just calls me It's always 'Mary Christmas'." Ql SZfhO fYPV MISSES' FAMOUS MAKER COORDINATES tJVfmtJJ lT JT Orig.

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