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The Philadelphia Inquirer from Philadelphia, Pennsylvania • Page 13
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The Philadelphia Inquirer from Philadelphia, Pennsylvania • Page 13

Philadelphia, Pennsylvania
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Monday, March 19, 1979 Philadelphia Inquirer 5-B FDA doctor: Test drug on children jZ: the difficulty of finding suitable groups on which to test the experimental vaccine. He said: "I would like to suggest that there are children throughout the United States who are on a waiting list to be admitted to various institutions fcr the retarded It would seem to me that this particular group at home, not in the institution, would be a logical group in whom to consider trials with hepatitis vaccine." Krugman said he felt such tests would be "highly ethical," because the chances of a child's becoming infected with hepatitis after entering an institution for the retarded are very high. Crowded and unsanitary conditions and poor personal hygiene help spread the disease. Other medical authorities and gov ernment officials vehemently disagree with the proposal. Carleen Bridgeman, executive rector of the Institute for the Study of Medical Ethics in California, Called Krugman's proposal "scary" and said, "It's using a captive subject a child unable to give informed consent." Dr.

John Cooledge said, "Dr. Krugman's idea is unconscionable until safety is established. His suggestion is completely unethical." Cooledge, director of health services at the Georgia Retardation Center, is also a special consultant in the court-ordered cleanup of Willowbrook State School for the retarded in New York. Part of the reason for the angry reactions from Cooledge and others is Krugman's controversial role in operating a research program at Willowbrook throughout the 1960s that involved infecting healthy retarded children between the ages of 3 and 10 years old with live hepatitis. Krugman's early experiments, in which he measured among other things the amount of antibodies-natural defenses the children developed after he infected them with the disease, provided great gains in scientific knowledge, including the discovery of two separate hepatitis 'Krugman's series of studies at Willowbrook laid the groundwork for our current understanding of hepatitis," said Dr.

Franklin Tyeryar, hepatitis program officer for the National Institute of Allergy and Infectious Diseases. But Krugman's methods have left a bad taste in the mouths of many scientists. United Press International IN PAPAL HANDS is a six-month-old girl at San Giuseppe, in suburban Rome where Pope John Paul II visited yesterday. Bw CM UlEo ime PC2I E29 Em3 E53 E29 KE23 SSSSSSSSS3l ES3 BS3 Bb3 KS3 E9 Blood test will aid heart attack detection By Bob Wyrick Newtdav Service WASHINGTON One of the government's chief health advisers has touched off an angry debate within the medical community by suggest-. ing that retarded children be used as subjects for testing an experimental vaccine made from the diseased blood of hepatitis victims.

The hepatitis vaccine in question has not been licensed by the Food and Drug Administration (FDA). A spokesman for the vaccine's manufacturer, Merck Sharp Dohme, said that testing is in the early stages and that the vaccine has not yet been proven safe or effective. Although no researcher has accepted the proposal to test the vaccine on retarded children, no FDA rule prohibits such experiments, according to agency spokeswoman Faye Peterson. While the agency has promulgated detailed guidelines to safeguard prisoners, for example, who are often used in medical experiments, no similar rules have been issued that specifically cover retarded children. The proposal to use retarded cfcil-dren as test subjects of the vaccine for the potentially fatal disease was made by a New York pediatrician, Saul Krugman, during a workshop on the experimental vaccine hell two months ago at the National Institutes of Health (NTH) near here.

A distinguished hepatitis researcher, Krugman is also chairman of the vaccine board of the FDA's bureau of biologies, the chief federal advisory board for reviewing the safety and effectiveness of vaccines to determine whather they should be licensed. Krugman, when asked at the Jan. 19 NTH workshop to summarize the material presented there, addressed Plans begun in Tokyo for industrial summit Associated Press TOKYO Henry Owen, President Carter's special assistant for economic affairs, arrived in Tokyo yesterday to help prepare for the June summit meeting of industrialized nations in the Japanese capital. Representatives of the participating nations are scheduled to hold their first pre-summit planning session Thursday. Owen also will meet Prime Minister Masayoshi Ohira and other Japanese leaders for talks that are likely to touch on the huge trade imbalance between Japan and the United States.

USA tient will have suffered undue anxiety and expense. On the other hand, Burnam said, there have been instances where patients discharged on the basis of the enzyme test have died hours later of a coronary, because the tests were not sensitive enough to uncover the trouble. The new test, as does the old, measures the level of an enzyme that the heart muscle releases when it has been damaged, but the doctors claim the new test is 3,000 times more sensitive. As a result, a diagnosis can be made in the presence of a much lower level of the enzyme and consequently at an earlier stage of heart damage. It can be done within two hours after the onset of chest pain, the physician said.

The enzyme sought is cretine kinase MB, or CK-MB, as it is called. Unlike the several enzymes measured by previous tests, which are found in other parts of the body, significant amounts of CK-MB are found only in heart cells, thus its presence in blood is an almost positive indication that it is the heart and not some other organ that has been damaged. Previous methods were not able to detect significant amounts of CK-MB. In addition to its diagnostic application, the physician said that the test makes possible new insights into the process of a heart attack. "We have learned there is a group of people who are releasing small amounts of enzymes literally having mini-heart attacks," Shell said.

By Harry Nelson Lot Anaeles Timet Service LOS ANGELES A new blood test will enable doctors to diagnose a heart attack within two hours, instead of the two days now required for similar tests, two Los Angeles heart specialists report. The new test is also more accurate than existing diagnostic methods, according to Dr. William E. Shell of Cedars-Sinai Medical Center and Dr. Michael E.

Burnam of the Medical School of the University of California at Los Angeles. The doctors, who spent the last three years developing the test, said that its speediness not only made earlier treatment possible, but also may result in substantial savings. They explained that about 3 million adults are hospitalized each year with chest pain. Determining whether the problem is a heart attack, indigestion or something else is difficult in many cases. The current diagnostic procedure involves giving the patient a physical examination, an electrocardiogram (EKG) and a blood test aimed at measuring the levels of three particular cardiac enzymes that help doctors assess damages to the heart.

But Burnam and Shell told a news conference that the EKG is only 50 percent reliable for that purpose, and existing enzyme tests often require the patient to stay in a coronary care unit two to three days before a definitive diagnosis can be made. If the tests are negative, the pa 0 Now It's Doubly Delicious, and treat a friend to The Unique fl Sandwich of A America DTheu.SA-the Unique Sandwich of America from Chick-fil-A. A tender, boneless breast Dof chicken, seasoned just right, lightly fried and served on a hot buttered Dbun. It's the taste sensation that's sweeping the nation. DWith this coupon, you can discover the sensa your discovery.

But hurry. This offer ends on April 15th. Until then, use this coupon to buy one USA and get one free. That makes the U.SA doubly delicious. Limit only one free sandwich per coupon.

a rhe Gallery at Market East Granite Run Mall. Media Exton Square Mall. Exton Cherry Hill Mall, Cherry Hill Echelon Mail, Voorhees PE tional taste of the U.S.A. ADVERTISEMENT ADVERTISEMENT ADVERTISEMENT ADVERTISEMENT ADVERTISEMENT ADVERTISEMENT NEW 'HUNGER-FREE' SYSTEM SOLVES 40 POUND PROBLEM! tmjgi By Sue Hart Special Writer Mary Lou Taddonio has been on a merry-go-round of weight loss and weight gain for seventeen years. Her weight problem first surfaced when she was 14.

About the time other young girls were discovering boys, Mary Lou was tipping the scales at 156 pounds. She spent the next three years dieting and graduated from high school weighing 132 pounds. Listening to the vivacious mother of two describe her past adventures in yo-yo dieting is like taking a ride on a roller coaster. Doctors' diets, diet clubs, do-it-yourself diets: you name it, Mary Lou has tried every means of weight reduction possible. The only constant in her battle of the bulge was the fact none of the diets really ever worked for her.

The sunlight caught the I 1 1 I 1 'aJ wen i-4V 'H 1 If (i 1 I I' V' Obviously all aspects of the Weight Loss Medical Centers program really paid off for Mary Lou. She lost 40 pounds and she successfully kept that lost weight off. She has been swamped with compliments regarding her new figure and her younger appearance. She was recently asked to show her I.D. at a bar! Things like that never happened to Mary Lou when she was size 18.

She described how self-conscious she was whenever she went out and how difficult it was to shop for doming. "Everything I tried on, I remembered Mary Lou. It was especially difficult to find youthful styles in a size 18. But now that Mary Lou is a size 12, all sorts of nice things are happening. She took up jogging shortly after she started the Centers diet and buying jogging shorts and all sorts of new clothes in a size 12 has been a delightful experience for her.

And, at least five people who watched Mary Lou blossom into a pretty, young woman have since signed up for Weight Loss Medical Centers program. They say, imitation is the highest form of flattery! But the nicest thing that has occurred since Mary Lou lost 40 nrmnHs nt Wpicht Toss Medical Centers is her husband's reaction to the "new" Mary Lou. He recently gave her a very special present, a delicate, gold necklace, "for losing the Mary Lou said she was so happy and so touched by his though tfulness that she cried. So it is a fairy tale ending for a story that began as a young woman's desperate, last resort attempt to lose weight. NOTE: Weight Loss Medical Centers operates twenty-three offices throughout the Greater Delaware Valley.

To arrange a no-obligation consultation about individual weight problems and to locate the office most convenient to you the phone numbers are: in the Philadelphia area (215) 885-5690; in New Jersey (609) 735-5797; in Delaware (302) seventeen years of starving herself to no avail on other diets, the fact she was not hungry on the Weight Loss Medical Centers program was a major reason for her success coupled with the fact that she didn't have to make any decisions about what foods to eat and not to eat The program is based upon flie Centers own specially formulated, nutritionally safe food line called "Nutri System Pre-packaged and re-measured, Nutri System 2000 eliminates the need to count calories, weigh food portions or make any food decisions whatsoever. "It is hassle-free it's very said Mary Lou, "and if convenient, too. I brought it to work with me." Nutri System 2000 provides the dieter with satisfying, low calorie, low fat, low carbohydrate and high protein meals. And there is an ample selection of dishes to provide a wide variety of meals from soups to milkshakes to pancakes to entrees served in savory sauces. According to Mary Lou, at least one of the entrees, a chicken dish served with crepes, was so filling she could barely finish it all.

Besides never feeling hungry, another plus of the nationwide Centers program for Mary vision. Each Center is staffed by a doctor, nurses, weight counselors, a behavior modification therapist and an exercise instructor. Being monitored on a regular basis by a medical staff is a key element of the Centers entire program. This supervision insures the dieter is properly following the diet to achieve his safe maximum amount of weight loss within a minimum amount of time. Some Centers have reported weight losses as great as a pound a day or more but people vary and so do their weight losses.

Because of this, the Centers calculate each dieter's potential weight loss individually. Another highlight of the program for Mary Lou was the behavior modification training she received from a trained Before enrolling at Weight Loss Medical Centers Mary Lou Taddonio had tried every diet that came along without any measurable success. reddish gold highlights in her brown hair as hazel-eyed Mary Lou explained why none of the diets she experimented with were successful: The main problem was I wasn't eating very much so I was always hungry. Not only was I always hungry but I felt so tired on other diets I tried so I would eat more to feel Alter years of vain attempts at dieting. Mary Lou met her downfall two years ago.

She got a job in an of ice with 28 people who celebrated every birthday and special occasion with cakes and other tempting goodies. Within two years, Mary Lou had gained twenty pounds. To add to her misery, Mary Lou's husband Carl can be a real tyrant when it comes to weight or, at least, that is how Mary Lou viewed the situation. "He was so terrible about my weight complained Mary Lou, he never took me But Carl, who is tall and slender, had good reason to be concerned. He had watched his bride zoom up from 135 pounds to 182 pounds.

Only half-jokingiy, Mary Lou expressed concern that if she did not tackle her weight problem After Mary Lou lost 40 pounds and 3 dress sizes on Nutri System food her husband gave her a gold necklace "for losing all that "weight Coupled with the Centers maintenance program, these sessions actually leach the dieter better eating habits. Mary Lou said, "Now I'm very conscious of carbohydrates and calories I read aU die labels (listing ingredients of One pointer Mary Lou picked up in behavior modilicatior training was restricting her eating of meals at home to just one room. This avoids the temptation to snack in front of the T. V. and it makes the dieter more aware of what thev are estins.

Mary Lou has kept that lost weight off for four months and now intends to return to the Centers to achieve her ideal weight of 135 pounds. "It does exclaimed a now-gleeful Mary Lou about the Weight Loss Medical Centers program. And it works without drugs, strenuous exercise or fasting. "I was never hungry on the program," said Mary Lou, "I had alot of pep and I never felt tired." Now employed in data processing at a local bank, Mary Lou admitted her coworkers would greet her comments about not being hungry with "You're Of course, for Mary Lou, after successfully and soon, she might lose her husband. Then Mary Lou spotted an ad for the Weight Loss Medical Centers in her local newspaper.

She did not even tell Carl she had enrolled in the medically supervised, quick weight-loss program until after she had dropped her first ten pounds. Upon hearing her news, Carl's reaction was, "Good you've only got thirty more pounds to go." Well, Carl was in for a great surprise. Within the first six weeks on the Centers diet, Mary Lou lost 26 pounds, then another 14 pounds, a total of 40 pounds, slimming her 5'6" frame down to 142 pounds..

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