The Morning News from Wilmington, Delaware • Page 40

C8 The Morning News, Wilmington, Delaware Friday, Nov. 19 1982 120,1 40 NYSE Volume in millions of shares 1118 1117 1116 1115 1112 1111 1110 1109 1108 Dow Jones Average 30 industrials Nov. 18, 1982 High 1040.47 1118 immmmmimmmmmimiammim 1117 BaaaaaBawBMaaMBMMM 1116 1115 1112 MMMMMM 1111 tmmmmmmmtmmmattmmmmmmm 1110 lmmmmmtmammmmtmmmlmm 1109 HMHwaMawManaaMMBaa 1108 Low 1020.05 Close 1032.10 Change 44.60 Byinini Voters seen as disliking Reaganomics, poll finds They think president should alter policies and interest rates, and that it will eventually lower unemployment. Respondents were also about evenly divided over whether Reagan will be able to reduce unemployment now at 10.4 percent. However, nearly half of those who said he will not reduce unemployment said it is because lowering unemployment is beyond any president's control.

Nearly six of 10 people polled said that Reagan's economic program has either helped the country or not made any difference, while eight of 10 said Reaganomics has either helped or made no difference to them personally. As with all sample surveys, the results of they oppose Reaganomics. Overall, the Democrats picked up 26 congressional seats in the Nov. 2 elections, prompting some GOP leaders to concede that some changes in Reagan's supply-side economic program might be needed to ease unemployment. In the poll, respondents were about evenly divided over which party is better able to handle the nation's economic problems, but split 46 percent to 27 percent in saying the Democrats are better able than the Republicans to handle the nation's unemployment problems.

Before the election, Reagan said many times that his economic program of tax and spending cuts has reduced the inflation AP-NBC News polls can vary from thV opinions of all Americans because of chance variations in the sample. For a poll based on about 1,500 interviews, the results are subject to an error margin of 3 percentage points either way because of chance variations. That is, if one could have talked this past week to alL' Americans with telephones, there is only 1 chance in 20 that the findings would vary by more than 3 percentage points. Of course, the results could differ from. other polls for a number of reasons.

Differs ences in the exact wording of questions, differences in when the interviews were conducted and different methods of inter-j viewing could also cause variations. For the national telephone poll, 1,583 adults were interviewed Monday and Tuesday in a scientific random sampling. The poll said about half the people who voted earlier this month cast their ballots for congressional candidates according to how they felt about Reagan's economic policies. Forty-three percent of the people who voted for a Republican congressional candidate said they did so because they support Reagan's economic program, while 45 percent of those who voted for a Democratic candidate said they did so because By TIMOTHY HARPER Associated Press NEW YORK A majority of Americans think the outcome of the midterm elections was a signal for President Reagan to change his economic policies, according to an Associated Press-NBC News poll. In the poll, 56 percent said the election results indicate that people are generally displeased with Reaganomics.

In a follow-up question, 54 percent said the outcome of the elections means the president should change his economic policies. "i Cancer-fighting hope is seen for Hercules drug Wall Street report Market up slightly; investors wait for interest rates to drop New Ynrk Times NEW YORK Slock prices rose moderately Thursday in slower trading following Wednesday's sharp rally. At the final bell, the Dow Jones industrial average was ahead 4 60 points, to 1.032.10. In the previous session, the blue-chip barometer soared 19.50 points on renewed expectations of a reduction in interest rates. Leonard Siegel, vice president of investments of Josephthal said the market continued to be buoyed mainly by the belief that the Federal Reserve "will shortly cut the discount rate." The rate, now at 9 lz percent, is what the Fed charges banks for loans.

Siegel noted that if this occurs the Dow could surpass its high of 1,065.49 set Nov. 3. He said that President Reagan's statement Wednesday that he is considering a proposal to move up to January the 10 percent tax cut scheduled for July also helped stock prices. Business briefs Stall photo by Chuck McGowen David S. Breslow, Hercules Inc.

researcher. By HENRY F. DAVIDSON Staff reporter Some scientists at the National Cancer Institute consider a Hercules Inc. co-polymer to be "a leading candidate" in the class of anti-cancer drugs that stimulate the body's immune system to destroy tumors. David S.

Breslow, who created and has been working for a quarter-century on the biologically active co-polymer now called MVE2 was given the Delaware Section Award of the American Chemical Society Wednesday night at the Hercules Country Club. Since the 1940s, Hercules has been a leader in creating and manufacturing water-soluble polymers, which are usually in powder form, used to thicken water. One Hercules polymer is used to thicken oil-well-drilling mud, so stone chips and other drillings can be easily brought to the surface. The same polymer is used to inhibit crystallization in ice cream and as a thickener in salad dressings and many beauty products. An example of a natural water-soluble polymer is pectin, which is used as a thickening agent in making jellies and jams.

MVE2 is an acronym of the two ingredients: maleic anhydride and vinyl ether, both relatively cheap chemicals. "When you look for a new water-soluble co-polymer, except in the pharmaceutical field where price is not important, you want it to be cheap as well as inexpensive to manufacture," Breslow said. "Chemical laboratories are littered with the ghosts of excellent polymers that are too expensive to market." When the first polymer from these two chemicals was reported 25 years ago, Breslow said he was attracted to it because it was water-soluble. Then, the National Cancer Institute reported that an early sample had biological activity. "We're not sure how it works." he said.

"These polymers are elec-trically charged they are administered as a salt "and a large number of polymers with a negative charge are known to have similar biological activity. "This particular one has a much better therapeutic index; that is, the effective dose is much lower than the toxic dose. Any drug that does any good is toxic to some extent." The original co-polymer was a mixture of relatively long chains of the two parent molecules. (A homo-polymer, like polypropylene, is a chain of one kind of molecule, or monomer.) Breslow said the material was quite toxic and a great deal of time went into making shorter chains. "If they are too short, the biological activity almost disappears; if they are too long, the drug is too toxic." As reports were published in scientific literature, Hercules mailed out more than 3.000 samples all over the world.

"I was recently asked how much all this work cost Hercules and figured I nickeled and dimed the company for nearly $300,000 over the years. To the company's credit, no one had ever objected, even though we were not in the pharmaceutical business in the early stages." MVE2 was found to be effective against such a broad spectrum of viruses, bacteria and fungi and against a form of mouse lung cancer, called Lewis Lung Carcinoma, and also against mammary cancer and malignant melanoma in mice, that Breslow said it was obvious MVE2 doesn't attack the target directly: "It seems to do something to the host itself." Michael A. Chirigos, who earned his master's degree in biochemistry at the University of Delaware in 1954, was in charge of the studies at the National Cancer Institute and is among those who consider MVE2 a promising drug. Chirigos said in a telephone interview that it is classed as an immunomodifier. Specifically, the co-polymer stimulates two kinds of white blood cells to rush to the body's defense by destroying cancer cells and other foreign bodies such as viruses.

The National Cancer Institute recently ended its animal trials of MVE2 but Chirigos said the co-polymer is still under intensive study to find out how it works. Hercules' jointly owned pharmaceutical company, Adria Laboratories in Columbus, Ohio, has picked up the studies with approval from the Food and Drug Administration and is conducting human tests, which could take years. These are done with consenting terminal cancer patients as the research seeks to find a therapeutic dose. Breslow said no one expects MVE2 to effect cures. Rather, it is thought of as a mopping-up operation after most of the tumors are removed with chemotherapy, surgery or radiation.

One of the tragedies of cancer is that, after a tumor appears to be successfully removed, a few surviving cancer cells grow and the cancer, returns, often in another part of the body. Cleaning up the last cells is a primary goal of medicine. Breslow, 66, said his interest in chemistry began in New York when he was a boy, after he and a friend inherited a chemistry set. One day they ran out of ferrous sulfide and couldn't make more stink bombs. They tried to substitute ferrous sulfate, without success, and this led him to wonder why two chemicals with such similar names acted so differently.

Chrysler, UAW to resume negotiations DETROIT Chrysler Corp. and the United Auto Workers union said Thursday that they will return to the bargaining table over the weekend in the United States and Canada in search of an early end to a strike by 10,000 Canadian auto workers that has had an increasingly severe effect on Chrysler operations in the United States. Canadian and U.S. union leaders, reacting to what they consider signals that Chrysler is prepared to improve its wage otter, agreed to a resumption of talks after a two-hour strategy session at UAW headquarters here. Talks will begin Saturday in Toronto and Monday in Detroit, as the UAW and Chrysler seek to negotiate separate contracts with Chrysler in the two countries.

Union officials apparently do not expect quick results, however. The early talks will focus on such questions as absenteeism rather than the critical wage issue, and UAW President Douglas Fraser has left the country on a previously planned trip. Ford closes small-car plant in California Ford Motor Co. is shutting down its Milpitas, assembly plant employing 2.386 union workers. The 27-year-old factory will cease operations by June 1, 1983.

a company official said Thursday. Ford blamed much of the problem on the fact that up to 70 percent of the small cars sold in California are imported autos. The plant, which makes the small Escort. Lynx. EXP and LN7 automobiles and light trucks, employed 4.500 union workers two years ago in this city of 40,000 just north of San Jose.

The area already was suffering from industrial cutbacks, including the shutdown of a General Motors Co. plant nearby which closed for good in March, idling 6,500 workers. Steel union meets amid concessions talk The United Steelworkers' executive board met privately Thursday in Pittsburgh to discuss a new contract amid reports that local presidents would be asked to vote on concessions. At least one union official said the board already has reached a tentative agreement on a new pact to replace the current contract, which expires in August 1983. "We've known about it for three days," said Mike Bonn president of USW Local 2227 at U.S.

Steel Irvin Works. He insisted steelworkers would reject any cuts unless the industry's eight largest steelmakers promise to recall some of the nation's 130,000 furloughed steelworkers. FCC rejects Bell bid for connections hike The Federal Communications Commission rejected Thursday a series of rate hikes proposed by the Bell System for certain connections used by its long-distance competitors and telegraph carriers. By a 6-to-1 margin, the FCC said the Bell System companies and their parent, the American Telephone Telegraph had failed to abide by the terms of a 1974 settlement in developing the proposed rates. i The decision was a victory for long-distance competitors, who recently absorbed a 50-percent increase in certain other charges they must pay the Bell System for connections to local phone switches.

A fare fight airlines war for winning ticket By CHRISTOPHER LINDSAY and Dec. 14. Trips must begin and end on a Tuesday or Wednesday, with a layover at least through a following Saturday with a maximum stay of 60 days. Capitol, however, requires the return trip be by Dec. 14.

The ticket must be purchased at least seven days in advance. A round-trip ticket must be bought, at $198. Capitol will sell a one-way ticket with no return date required. Seats available for the discount on the nine daily flights involved are limited. The new fare cuts $40 from the prevailing advance purchase, round-trip fare for midweek transcontinental flights.

The nation's airlines, which are struggling in the third year of a severe slump, have been trying to avoid price wars. Their losses began to mount in 1980, when they were hit with the double blow of a recession and skyrocketing fuel prices. That year, the major airlines lost about $250 million. In 1981, the cutbacks and confusion from the controllers' strike added another burden, and the big airlines lost $500 million. This year's recession brought the demise of Braniff International and Laker Airways and predictions that other lines also might fail.

Industry analysts expect losses to hit $1 billion by the end of the year. Why are the major airlines so quick to jump in with money-losing fares when tiny competitors attempt to snag a small portion of the market? "We don't intend to lose out to airlines that choose to hold sales 365 days a year," Richard Ferris, chairman of United, told New York security analysts this week. He said an airline can either lose money or lose customers. "We don't like either alternative very much, but the first matching fares is a bit' more palatable." Associated Press NEW YORK A transcontinental air fare war broke out Thursday as two big carriers matched a $99 one-way fare set by an upstart competitor, but the bonanza for travelers is severely restricted. The low fare was set Tuesday by Capitol Air, a former charter carrier that launched scheduled service between New York and California after the airline industry was deregulated in 1978.

It was matched Thursday by United Airlines and Trans World Airlines. American and Eastern airlines and Pan American World Airways were all considering their response, spoksemen said. The deal has numerous hitches: The fare is good only on non-stop flights between New York and San Francisco, Los Angeles or San Jose, Calif. It is good only for trips begun between Nov. 30 Wilmington enjoys the fruits of shipping company's labor By ED COHEN Staff reporter The first piggyback cars of CSX new Orange Blossom Special rolled into Wilmington late Tuesday night, carrying fresh citrus fruit and tomatoes loaded hours earlier in Orlando, Fla.

Piggyback cars are railroad flatcars topped with truck trailers, and the Orange Blossom Special can carry 100 or more of them six days a week from a depot in Orlando non-stop to the Baltimore Ohio Railroad's Wilsmere Yard, between Elsmere and Richardson Park. There, trailers are hitched up to take the produce to market all over the Northeast. The Orange Blossom Special is part of a new door-to-door shipping service from CSX, the nation's second-largest railroad in route miles. That service is designed to compete with trucking companies that now haul the lion's share of Florida produce to northern markets. The train will leave Orlando at 2 every morning except Monday Florida farmers don't pick on Sundays and travel along the CSX's Seaboard System Railroad tracks to Washington, C.

From there, it will run on Chessie System tracks to Wilmington, arriving at 4 the next morning. The Railroad is part of the Chessie System. "We wanted to be able to reach the produce markets in the Washington, Baltimore. Wilmington, Philadelphia, New Jersey and New York City areas," said Mark Sullivan, spokesman for Seaboard System. has a fine location in Wilmington for an expanded piggyback ramp.

"Our only alternative would have been going to Philadelphia, and that area is more congested. Wilmington is really ideally located." At the Wilsmere yard, a huge rolling crane called a "piggy packer" takes the trailers off the flat cars. possible, then the truckers came along and took it all away from us." Trains carried nearly all fruit and vegetables to tne Northeast in the 1950s. They started to lose the market during the 1960s and had virtually nothing left by 1970J Sullivan said. Railroad officials won't say how much they expect to haul of the millions of tons of produce that leaves Florida for the Northeast each year.

"I don't want to talk profit," Sullivan said. "But it is a profitable business, which is why we're making ari investment." Sullivan said railroad officials aren't disappointed' that only 10 trailers were carried on the first run which arrived about seven hours early. Seaboard bought 400 trailers for the program and CSX spent thousands of dollars on the Wilsmere Yard. They say the service, like the citrus-picking season is just getting started. Trucks hired by CSX take the produce to markets and food distribution centers.

The service has added eight jobs at the Wilsmere Yard, four clerical and four mechanical, the station master said. The railroad expects to double that in six months and add more people as traffic requires. The train named after the famed luxury passenger train that once ran between Florida and the Northeast will turn around and carry goods from northeastern factories back to Orlando, after a stop in Jacksonville. Government deregulation of railroad schedules, routes and shipping rates made the new venture possible, CSX officials said. The merger a year and a half ago of Chessie and Seaboard also helped.

"We know this is a $200-million-a-year business and it has all belonged to the truckers up to this point," Sullivan said. used to all belong to the railroads. We invented the refrigerated and ice cars that made it fi: 12 2 2 222" 22222222222222222222 22212 2 a.