St. Louis Post-Dispatch from St. Louis, Missouri • Page 34

12C ST LOUIS POST-DISPATCH SUNDAY, FEBRUARY 4, 1996 OBITUARIES Sister Jane Marie Dempsey; Retired Teacher William Alfred Stern; Volunteer, Benefactor Fabian L. Sickles, 72; Longtime Owner Of Firm That Provided Legal Photography Fabian L. Sickles, a legal photographer in St. Louis for many years, died Wednesday (Jan. 31, 1996) of cancer at his home in north St.

Louis County. He was 72. Since the late 1940s, Mr. Sickles to 1971 and again from 1977 to 1983. She later was director of the Visitation Alumnae Association and director of the Sodality of the Children of Mary.

She retired in 1990. A funeral Mass will be celebrated at 9 a.m. Tuesday in the chapel at Visitation Academy, 3020 North Bal-las Road, Town and Country. Visitation will be from 4 to 8 p.m. Monday in the chapel at the academy.

Burial will be in Calvary Cemetery. Among survivors are a sister, Sister Margaret Jane Dempsey, a Sister of Mercy, of Creve Coeur; and three brothers, John J. Dempsey of St. Charles, Richard B. Dempsey of Chesterfield and David G.

Dempsey of St. Louis. Sister Jane Marie Dempsey, former teacher and mother superior of the Sisters of the Visitation, died Saturday (Feb. 3, 1996) at the Visitation Monastery in Town and Country cf complications from Sjogren's syndrome, a disease of the mucous membranes. She was 79.

Sister Dempsey was born and grew up in St. Louis. She entered the order of the Sisters of the Visitation in 1935 and took her final vows in 1940. She graduated from the Visitation Academy in Town and Country and earned a bachelor's degree in English and a master's degree in Latin, both from St. Louis University.

For 40 years, she taught elementary school and Latin and English in high school at Visitation Academy. She was mother superior from 1965 William Alfred Stern, a former volunteer and benefactor in St. Louis, died Saturday (Feb. 3, 1996) of infirmities at Gatesworth at One McKnight Place. He was 101 and had lived in Clayton.

For many years, Mr. Stern did volunteer work and supported Jewish Hospital. He was also a patron of the Missouri Athletic Club and Temple Israel congregation. He was an avid golfer and played at the Triple A Golf Club in Forest Park until he was 90. At 89, he won a golf tournament for octogenarians at the club.

Mr. Stern was born March 22, 1894, in Pittsburgh and raised in Chicago. From 1912 to 1916, he was a run ner and set records for short distance running in the Amateur Athletic Union. He served in the Army Air Forces in World War and he played baseball and ran track for military teams. He also played amateur baseball in Chicago.

He moved to St. Louis in 1954, after retiring as a buyer at a department store in Little Rock, Ark. The funeral service and burial will be private. Mr. Stern's first wife, Lois Gottlieb, died in 1946.

Among the survivors are his wife, May Popper Stern; two daughters, Joan Abrams of Frontenac and Patsy Rubin of Peoria, seven grandchildren; and 11 great-grandchildren. ties at Roi-Namui, Saipan, Tinian and Iwojima. After the war, he returned here and started his business. A graveside service will be 1 1 a.m. Monday at Jefferson Barracks National Cemetery, 101 Memorial Drive, Lemay.

Among the survivors are his wife, Ruth Sickles; two daughters, Mary Ann Warner of Ballwin and Martha Sickles of Maryland Heights; two sons, David Sickles of St. Louis and Fabian L. Sickles II of Affton; and two grandchildren. Memorial contributions may be made to the American Cancer Society or to a charity of the donor's choice. was trie owner ot Fabian L.

Sickles Legal Photography, now F.L. Sickles and Sons which specializes in photograph- A I ing and documenting evidence for ciMB le8al Proceedings. bicKies While serving jj, the Marines during World War II, he trained as a combat photographer. He photographed the terrain and bat- POLICECOURTS yOtBSOIiRiiiCMiCOCs filDO'Cs (ffiJ 'mm ii The following incidents were among those that were reported to police departments in the St. Louis metropolitan area or that involved action in one of the area's courts: A fl-'-H 'A Ml VIOLENT DEATH St.

Loiiif Dwight Collins, 23, was fatally shot about 9 p.m. Friday at his home in the 6300 block of Labadie Avenue. A suspect was taken into custody. A second victim suffered minor wounds. '-t t.i i.

FATAkC ACCIDENTS Jefferson County: Stephan 44, of High Ridge, was killed about 1 a.m. Saturday when his 1962 Ford pickup ran Off an exit ramp in northern Jeff- i i i Vfl 1 -i i J-' 4 i I I i i r. I Terson County. The Missouri i Highway Patrol said Candrl was getting off old Missouri 21 onto new Missouri 21 when he lost control of the pickup and it ft overturned'. Ste.

Genevieve County: James Arringtpn, 28, of killed about 10:15 p.nt. Friday when his 1978 Ford Mustang ran off U.S. Highway 61, about two miles south of i Route Q. Police said Arrington's car veered off the left side of the highway, struck an embankment and overturned. Arrington was from the car.

Cardizem CD and CardiSense May Help You Live Well Talk to your doctor or health care professional about Cardizem CD. Only a health care professional authorized to prescribe Cardizem CD can evaluate the potential risks and benefits of Cardizem CD for you. Call for a free brochure on high blood pressure or angina, plus one free copy of CardiSense. Deadline For Media Scholarship Is Nearing College students studying print or broadcast journalism, advertising or public relations have until March 29 to submit completed application forms for scholarships administered by the Journalism Foundation of Metropolitan St. Louis.

Applicants must be full-time students in the fall and have completed their freshman year by then. They may attend college anywhere but must have home addresses in St. Louis city or county, the Missouri counties of Franklin, Jefferson, Lincoln, St. Charles or Warren, or the Illinois counties of Bond, Clinton, Jersey, Madison, Monroe or St. Clair.

Last year's program awarded more than $18,000 to 17 students. Applications are available from Joe Kenny, the foundation's scholarship coordinator, in care of the St. Louis Review, 462 North Taylor Avenue, St. Louis 63108, phone (314) 0 o0fj)og Cardizem CD plus CardiSense may give you an opportunity to lead a healthier life. Cardizem CD gives: Effective control of high blood pressure or angina for many people Once-daily dosing A free quarterly newsletter, CardiSense, with timely information on nutrition, exercise, and maintaining a healthy lifestyle.

In clinical studies with Cardizem CD, the most common side effects, seen in less than 55 of patients, have been headache, dizziness, slow heart rate, heartbeat irregularities, and swelling of the ankles. Cardizem CD is not appropriate for all people, especially those with certain serious heart rhythm conditions. Make sure your health care professional knows about your medical history, including heart, liver, and kidney problems. Tell your health care professional about other medications you are taking because 01 possible drug interactions which could result in other potentially serious side effects. ONCE-A-DAY (diltiazem HQ) 120- Capsules See important additional information below.

In clinical trials of CARDIZEM CD capsules, CARDIZEM tablets, and CARDIZEM SR capsules involving over 3200 patients, the most common events (ie, greater than 1) were edema (4 6), headache (46). dizziness (3.5). asthenia (2.6), first-degree AV block (24). bradycardia (1.7), flushing (14), nausea (1.4). and rash (1.2).

In addition, the following events were reported infrequently CutMoginnli. utjgeni). ImoalrmsnloJ ftrtlUJjL A 24-month study in rats at oral dosage levels of up to 100 mgkgday and a 21 -month study in mice at oral dosage levels of up to 30 mgkgday showed no evidence of carcinogenicity. There was also no mutagenic response in vitro or in wo mammalian cell assays or In vitro In bacteria. No evidence of impaired fertility was observed in a study performed male and tenuie rats oral dosages ot up to 100 mgkgday.

Pjtgnigq Category C. Reproduction studies have been conducted in mice, rats, and rabbits. Administration of doses ranging from five to ten times greater (on a mgkg basis) than the dairy recommended therapeutic dose has resulted in embryo and fetal lethality. These doses, in some studies, have been reported to ceuse skeletal abnormalities. In the perinatalpostnatal studies, there was an Increased incidence of stuibimts at doses of 20 times the human dose or greater.

There are no weH-rxmtrolled studies In pregnant women; then-fore, use CARDIZEM hi pregnant women only If the potential benefit lusohes the potential risk to tne fetus. Hurting Mothen Diltiazem is excreted in human milk. One report suggests that concentrations in breast milk may approximate serum levels. If use of CARDIZEM is deemed essential, an alternative method of infant feeding should be instituted. Pidlitrti Um Safety and effectiveness in children have not been established.

ADVERSE REACTIONS Serious adverse reactions have been rare in studies carried out to date, but it should be recognized that patients with impaired ventricular function and cardiac conduction abnormalities have usually been excluded from these studies. The following table presents the most common adverse reactions reported hi placebrKontrolled angina and hypertension trials patients receiving CARDIZEM CD up to 360 mg tiess man i) angina or nyperrenston mas: Cartiovtmlar Angina, arrhythmia. AV Otoe (second- or third-degree), bundle branch Mock, congestive heart failure, ECG abnormalities, hypotension, palpitations, syncope, tachycardia, ventricular extrasystotes Nervals System Abnormal dreams, amnesia, depression, gait abnormality, hallucinations, Insomnia, nervousness, paresthesia, personality change, somnolence, tinnitus, tremor 6anrelteitliiai Anorexia, constipation, diarrhea dry mouth, dysgeusa. dyspepsia, mild elevations ol SG0T, SGPT, LDH, and alkaline phosphatase (see hepatic warnings), thirst, vomiting, weight increase Demulological: Petechias, photosensitivity, pruritus, urticaria Other; Amblyopia, CPK increase, dyspnea, episraxis, eye irritation, hyperglycemia, hyperuricemia, impotence, muscle cramps, nasal congestion, nocturia, osleoarMular pain, polyuria, sexual difficulties The following postmarketing events have been reported infrequently in patients receiving CARDIZEM; alopecia, erythema multiforme, exfoliative dermatitis, extrapyramidal symptoms, gingival hyperplasia, nemorytic anemia, increased bleeding bme, leukopenia, purpura, retinopathy, and ttHombocytopsnia. In addition, events such as myocardial infarction have been observed which are not readily distinguishable from the natural history of the disease In these patients.

A numbet of well-documented cases ot generalized rash, characterized as leuko-cytoclastic vasculitis, have been reported. However, a definitive cause and effect relationship between these events and CARDIZEM therapy is yet to be established. Prescribing Information as ot April 1993 Marion MerreK Dow Inc. Kansas City, M0 641 14 mwmad Brief Summary of Prescribing information as of April 1993 CARDIZEM4 CD (diltiazem KCI) CftpMlM CONTRAINDICATIONS CARDIZEM contramdicated in (1) patterns with sick sinus syndrome except in the presence of a functioning ventricular pacemaker, (2) patients with second- or third-degree AV block except in the presence of a functioning ventricular pacemaker, (3) patients with hypotension (less than 90 mm Hg systolic). (4) patients who have demonstrated hypersensitivity to the drug, and (5) patients with acute myocardial infarction and pulmonary congestion documented by x-ray on admission.

WARNINGS 1. Cardiac CetidacthM. CARDIZEM prolongs AV node refractory periods without significantly proloriging stnus node recovery time, except in patients with sick sinus syndrome. This effect may rarefy result in abnormally slow heart rates (particularly in patients with sick sinus syndrome) or second-en (turd-degree AV block (13 of 3290 patients or 040S). Concomitant use of diltiazem with beta-blockers or digitalis may result in additive effects on cardiac conduction A patient with Prinzmetal angina developed periods of asystole (2 to 5 seconds) after a single dose of 60 mg of diltiazem.

2. Congests Heart Failure Although diltiazem has a negative inotropic effect in isolated animal tissue preparations, hemodynamic studies in humans with normal ventricular function have not shown a reduction in cardiac index nor consistent negative effects on contractility (dpdt). An acute study of oral diltiazem in patients with impaired ventricular function (election fraction 24 6) showed improvement in indices of ventricular function without significant decrease in contractile function (dpdt) Worsening of congestive heart failure has been reported in patients with preexisting impairment of ventricular function. Experience with the use of CARDIZEM (dtfbazem hydrochionde) in combination with beta-blockers patients with impaired ventricular function is limited. Caution should be exercised when using this combination.

3. Hygoteftsioi Decreases in blood pressure associated with CARDIZEM therapy may occasionally result in symptomatic hypotension. 4. Aula Hepatic MiW elevations of transaminases with and without concomitant elevation in alkaline phosphatase and bilirubin have been observed in clinical studies Such elevations were usually transient and frequently resolved even with continued diltiazem treatment hi rare instances, significant elevations tnzymn such as alkaline phosphatase. LDH.

SG0T, SGPT. and other phenomena consistent win acute hepatic inn have been noted. These reactions tended 10 occur early after therapy initiation (1 to 8 weeks) and have been reversible upon discontinuation of drug therapy. The relationship to CAflDIZEM Is uncertain it some cases, but probaNe in some. (See PRECAUTIONS.) PRECAUTIOUS Own! CARDIZEM (diltiazem hydrochloride) Is extensively metabolized by the liver and excreted by the kidneys and in bile.

As with any drug given over prolonged periods, laboratory parameters or renal and hepatic function should be monitored at regular intervals. The drug should be used with caution in patients with impaired renal or hepatic function. In subacute and criromc rJOQ and rat studies desined to produce tonicrty, high doses of dm azern were associated with hepatic damage In special subacute hepatic studies, oral doses of 125 mgkg and higher rats were associated with histological changes hi the kver which were reversible when the drug was discontinued In dogs, doses of 20 mgkg were also associated with hepatic changes; however, these changes were reversible with continued dosing. Dermatologicil events (see ADVERSE REACTIONS section) may be transient and may disappear despite continued use of CARDIZEM. However, skin eruptions progressing to erythema mutritorme andor exfoliative dermatitis have also been infre- reported.

Should a dermatologic reaction persist, the ouW discontinued. Dree Interactions Due to the potential for additive effects, caution and careful titration are warranted in patients receiving CARDIZEM concomitantly with other agon's known to affect cardiac contiacbhty andor conduction. (See WARNINGS I Pharmacologic studies indicate that there may be additive effects prolonging AV corKJoction when using beta-bloclcers or dtgitalis enncomrtantty With CARDIZEM. (See WARNINGS.) As with an drugs, can should be exercised when Ming patients wdh muhiok! medications. CARDIZEM undergoes biotransformation by cytochrome P-450 mixed function oxidase.

Cministration of CARDIZEM with other agents which follow the same route of biotransformation may result in the competitive Inhibition of metabolism Especially in patients with renal andor hepatic impairment dosages of similarly metabolized drugs, particularly those of low tmrapeubc ratio, may reouim admstment when starting or stopping corcomi-tanhV aOmmstered diltiazem to murium optimum therapeutc blood levels. eta-Woctm. Controlled and uncontrolled domestic studies suggest that concomitant use of CARDIZEM and beta-blockers Is usually well tolerated, but available data are not sufficient to predict the effects ot concomitant treatment In patients with left ventricular dysfunction or cardiac conduction abnormalities. Administration ot CARDIZEM (dituazem hydrochionde) concomitantly with propranolol five normal volunteers resulted In Increased propninotol levels in all subnets and bioavailability of propranolol was Increased approximately 50. In vitro propranolol appears to displaced horn its binr If combination therapy is initiated or withdrawn in coniunchon with propranolol, an adiustment the propranolol dose may be warranted.

(See WARNINGS.) ClimtidiM. A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58) and area-under-the-curve (53) after a 1-week course ol clmetidino at 1200 mg per day and a singe dose of diltiazem 60 mg. Ranitidine produced smaller, nonsignificant increases. The effect may be mediated by ctmetioine known inhibition of hepatic cytochrome P-450, the enzyme system responsible for the first-pass metabolism of diltuzem. Patients currently receiving diltiazem therapy should be carefully monitored for a change in pharmacological effect when inrtiating and discontinuing therapy with cimetidine.

An adiustment in the diltiazem dose may be warranted. Digitalis. Administration of CARDIZEM with tjigoxin In 24 healthy male subjects increased plasma digoxin concentrations approximately 20. Another investigator found no increase digoxin levels in 12 patients with coronary artery disease Since there have been contucting results regarding the effect of digoxin levels, it Is recommended that digoxin levels be monitored when initiating, adjusting, and discontang CARDIZEM therapy to avoid possible over- or under-digitalization. (See WARNINGS.) Anesthetics.

The depression of cardiac contractility, conductivity, and automaticity as well as the vascular dilation associated with anesthetics may be potentiated by calcium channel blockers. When used concomitantly, anesthetics and calcium blockers should be titrated carefully. CycloseortM A pharrnacoxinetic interaction between iitiazem and eveiosoonne has been observed during studies involving renal and cardiac transplant patients. In renal and cardiac transplant recipients, a reduction ol cyclosporins dose ranging horn 15 to 48 was necessary to maintain cyclosporins trough concentrations similar to those seen prior to the addition of diltiazem. II these agents are to be administered concurrently, cyclosporins concentrations should be monitored, especially when diltiazem therapy is Initiated, adjusted, or discontinued.

The effect of cydosporine on ditbazem plasma concentrations has not been evaluated. CartemaztaiM toncomrtant ailriiirtistration of diltiazem with carbamazepine has been reponed to result in elevated serum levels ol carbamazepine (40 to 72 increase), resuthng in toxicity in some cases Patients receiving these drugs concurrently should be monitored for a potential drug interaction. Forum To Discuss Regional Relations The Press Club of Metropolitan St. Louis is holding a luncheon forum to look at how St. Louis and the Metro East area can build stronger working relationships.

The forum will be at noon Feb. 14 "at the Collinsville Holiday Inn, 1000 Eastport Plaza Drive. James R. Pennekamp, executive director of the Leadership Council of Southwestern Illinois, will be the guest speaker. The council aims to encourage business and job development, enhance the area's image and improve the quality of life for Madison and St.

Clair county residents. Tom Dehner, associate director of community development and affordable housing for Alton, will moderate the program. Tickets are $12 for Press Club members and $15 for non-members. To make reservations, call (314) 241-NEWS. wrm rates in placebo patients snown tor comparison.

CARDIZEM CO Capsule nacobe-tMroM Angina aad Hypertension Thais ComWned Cardizem CD Placebo Adverse Reactions n607) (nJOl) 'Headache 54 5.0 Dizziness 3.0 30 Bradycardia 3.3 1.3 AV Ettocti Rrst Degree 3.3 0.0. Edema 26 1.3 ECG Abnormality 16 2.3 Asthenia 1.8 17 95370701 0954E5 1.