St. Louis Post-Dispatch from St. Louis, Missouri on September 8, 1963 · Page 24
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St. Louis Post-Dispatch from St. Louis, Missouri · Page 24

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Sunday, September 8, 1963
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Student Found Clue to Krebiozen Identity Shortly 24 A Sun- Sept. 8. I?63 I ST. LOUIS POST-DISPATCH U.S. Challenges AMA Figures On Rise in Number of Doctors NEWS ANALYSIS U.S. 'KIVF After Starting Work on 20,000 Spectrographs osteopaths who, by change m RESURVEY I j5r 'X. , :.(i. i ii r ' .1 ' .' T At f pa it i VP. n; f Took Part in Drug Investigation MRS. ALMA HAYDEN, one of fhe Food and Drug Administration scientists who identified tha drug Krebioien as creatine, in Washington with DR. ROBERT COGHILL of the National Cancer Institute center and DR.ELLIS LIPPENCOTT of Maryland University. ziiXt ft ; j : rj i w. n g l " S.VIET By JOHN M. HIGHTOWER WASHINGTON, Sept. 7 (AP)-The Kennedy Administration has started what one official termed a "massive resurvey" of its relations with South Viet Nam. The aim is to find ways of achieving the reforms which President John F. Kennedy considers necessary to victory in the Southeast Asian anti-Communist war. The problem is especially critical not only because of the situation in Viet Nam itself but because the United States seems to be suffering a decline in influence all over Asia. Effective influence the ability to get other countries to take action without having to threa-en or pressure them is what is meant by United States prestige abroad. This prestige, the capacity for strong leadership, has been damaged by several recent events. These include failure to unseat strongman Ngo Dinh Nhu from his position of power in the government of his brother, Ngo Dinh Diem. They include the almost contemptuous disdain shown for United States advice and criticism by the military junta ruling South Korea. Relations between the United States and Pakistan are on a more dignified plane but in terms of hard political realities cannot get much worse short of an actual break. Setback in Pakistan Under Secretary of State George Ball is evidently returning empty-handed from his talks this week with Pakistan President Mohammad Ayub Khan. United States differences with its kev Asian ally are centered on Pakistan's bitter opposition to United States military help to India and its consequent tlirta-tion with Communist China against which the Indian defenses are being raised. Even m relations with India, which has long received kid-glove treatment from Washington, the United States has found itself unable to make assistance a two-way street. The Indians have resisted United States efforts to set up a broadcasting station in their country lest this somehow infringe their asserted neutrality in the cold war. The spread of difficulties in re- ations between the United States and countries it is closely associated with are not limited, of course, to Asia. France Is the outstanding example in Europe. Under President Charles de Gaulle's leadership it long since decided to go its own way. But France is not dependent on United States support. Nor is another NATO ally, Portugal; the situation there is rather reversed since the United States needs continued use of air bases in the Azores despite the break between Lisbon and Washington over Portuguese co-Tonial policies in Africa. So far as officials can determine Ball is coming home empty-handed from Portugal, too, although there is hope that the Portuguese will not force closing the Azores bases. Difference In Quarrels White House and State Depart ment officials surveying tneir j trouDies say privately that there is a significant difference be tween quarrels with allies in Asia and those in Europe. In Asia the j government of a country like South Viet Nam can use tne argument that it is so weak that its government will collapse and the Communists will win if Unjted States aid is drastically cut. Such weakness Is, In fact, the greatest source of strength for Ngo Dinh Diem and his brother, Nhu, secret police chief. They know the United States cannot force a showdown which would destroy them without abandoning South Viet Nam to the Viet Cong forces backed by Communist North Viet Nam and Red China. The problem for President Kennedy is to find means of pressure which can force reforms, perhaps even make Nhu's NAM WASHINGTON, Sept. The Public Health 7 (AP) ! Service i disputed today a report by the American Medical Association indicating a sharp increase in the number of doctors in the United States. The Health Service said the report is contrary to the facts available to the service. The service issued a statement commenting on a press release last Sunday by the AMA Council on Medical Education and Hospitals dealing viVA physician-population ratios. "The AMA reported an increase of 29,000 physicians and an 1.9 per cent increase in the ratio of physicians of population between 1960 and 1963," the service said. It continued: "The 1960 figure of 246,712 physicians, however, does not include medical school graduates of that year, or foreign physicians who came to the United States temporarily for internship and resideiv.y training, fhe 1963 estimate does include these two catagories. In addition, it includes about 2000 California BREAKFAST IN BED DAILY PROMISED TO BRIDEGROOM SOUTHAMPTON, England, Sept 7 Brian Mooney, 19 years old, has a pledge from his bride-to-be: Breakfast in. bed every day of his life. Janet Bull, also 19, made the promise yesterday in winning a magistrate's permission to marry. Br.an's father, 61-year-old Robert Mooney, had objected to the marriage. "My son is petted and pampered by his mother," Mooney explained. "He won't get the same treatment on his honeymoon and the shock may ruin his marriage." "Nonsense," replied Janet. "I'll look after him just as well as his mother did. I'll give him breakfast in bed every day." That convinced the magistrate and it seemed to convince Brian's father. He wished the youngsters good luck as they left the court. D ALTON SAYS MISSOURI IS GROWING INDUSTRIALLY MONTGOMERY CITY, Mo., Sept. 7 (AP) Gov. John M. Dal-tcn reported today that Missouri was making good progress in its campaign for industrial development. "Missouri Is ready for industrial growth and we are getting it," he said. "We are bettering ourselves in higher education and research capability. We have vital transportation advantages and a wealth of natural resources. And we have a fine tax climate. "When we seek new industries to come to Missouri, we never have to apologize about our tax structure. The bare facts paint a picture tfiat industries like. Missouri will continue to remain below the national average in per capita collection of state and local taxes." GEN, WALKER'S SUIT ACCUSES unnniNRRARTFR OF SUNDER' win, . ...rr . liKtH.VlLLC. IV1133., sem. I (UPI) Former Maj. Gen. Edwin A. Walker filed a $2,000,000 slander suit today against Hodding Carter, Pulitzer Prize-winning edtitor-publisher of the Greenville Delta-Democrat Times. Walker based his suit on a speech Carter made at the University of New Hampshire last October, a month after Walker was arrested in racial rioting at the University of Mississippi. Walker charged that Carter defamed him in the New Hampshire speech, which he said was carried by newspapers and radio and television stations throughout the country. He said that Carter told the audience that Walker personally led the riots at the university. position untenable, without wrecking South Viet Nam's political structure and opening the way for the Communists. That apparently was what Mr. Kennedy meant when he said last Monday that without policy changes the war in Viet Nam could not be won but also said it would be a tragic mistake to cut off military assistance. tPI Radiophoto i jrjrj j IN VOTE CASE AT! MOUNT VERNON. 111.. Sept. 7 (UPI) A special Jefferson county grand jury investigating !legd election irregularities in the April Mount Vernon town-hhip election returned 59 indictments today a;;aint 22 per-onv'4ncluding three elected official!. Trie Jury returned one no-true bill 1m. Tnty-one of the 22 perioni Indicted are Democrats. Calvin Kirk, Democratic town-ahip-flopervisor and head of the relief office, was indicted on 11 courBS, including conspiracy, aiding iod abetting persons to vote illegally and vote-buying. Charles Waite, chairman of the county Board of Supervisors, an assistant township supervisor and chairman of the Board of Revftw, was indicted on three rounjs of conspiracy to buy votes; Gbel Wood, an assistant supervisor, was named in seven counU, including obstructing justiec by furnishing false information. Anwher apecial grand jury last My returned 19 indictments against 15 persons but the indictments were quashed because of irregularities In the selection of jurors. Kirk's wife, Arvella, was named in three counts today of aiding a voter to vote illegally, and Wood's wife, Ruth, was indicted on single count of illegally aiding a resident of another township to vote. Township employes who were lndiolad were: Helen Green, relief off lea employe, five counts of falsifying election documents. Mildred Henry, deputy town-chip clerk, one count of remov ing ballot from the office. Bob Shaw, Kirk's assistant, one count of Illegally taking a ballot and five counts of falsifying election documents. John Williams, relief office employe, for aiding voter to swi-BT falsely. Two persons, Cletus Rector and Dorothy Thomas, were indicted on counts ot perjury. George McGill was named in 10 counts charging conspiracy and vote-buying. George Thomason, who was defeated In the April election in an effort to become township highway commissioner, was the only Republican named in the election indictments today. He is charged in one count with removing a ballot from a polling place. State's Attorney Jay B. Stringer, a Republican and chairman of tha GOP county organization, aid ."some of the cases may com to trial next month. Stringer began the Investigation. ITALIAN PICTURE NAMED BEST AT VENICE FILM FESTIVAL ; VENICE. ITALY, Sept. 7 (AP) Thi Italian movie "Le Mani Sulla" Citta" (Hands Over the City) won the Golden Lion award, top prize at the Venice Film Festival, today. Britain's Albert Finney won the best male actor award for his role in the picture "Tom Jones," The best actress award went to France's Delphine Sey-rig for her part In the picture "Muriel." Thirty-one movies from 11 nations were shown at the two-weeK festival, but only 19, from rinerhations, were entered in the -Competition for the top prize. A seven-man jury made the decisions. TUG CAPSIZES AT NEW YORK; FOUR BELIEVED DROWNED NEW YORK. Sept. 7 (UPI)-A tugboat with 10 men aboard capsized in the East River today.' -The captain and three crcwrnembers were believed to have drowned. Six other crewmen were rescued. Rescued crewmen said the tug Flushing was towing a barge which moved up cm the tug, causing it to capsize and sink. The captain and crew members were hurled into the river when the tug struck the barge. The barge did not sink. Two policemen In a patrol car saw the accident and alerted rescue vessels. GOV, SCRANTON SELLS HOME WASHINGTON, Sept. 7 (UPI) Pennsylvania Gov. William W. Scranton, a possible dark horse for the Republican presidential nomination in 1964, has sold his Washington home to W. Averell Harriman, undersecretary of state for political affairs. An aid to Harriman declined to give the sale price, but it was understood that Scranton paid about $200,000 for the Georgetown residence when he bought it in 1959. At that time, Scranton was a member of the House of Representatives. BEER AS IMAGE IS BUST; BREWER SEEKS FAMILY IDEA MILWAUKEE, Sept. 7 (UPI) Beer has an image problem, Henry B. King, New York, president of the U. S. Brewers Association said yesterday. "Panty raids and beach busts are associated with beer. We want people to think of beer as healthful, family drink," he aid 22 ARE INDIC VERNON state law. have recently been granted M.D. degrees. This would make the actual net increase about 13,000." The health service added that the AMA figures for 1963 in-eluded all physicians in the United States, Puerto Rico, other American outlying areas and federal physicians here and abroad. The service said the AMA related this total only to the United States resident population of 188,000,000, "when, ta be accurate, the ra'o developed should have been based on the total of 192,000,001) persons who are served by these doctors." "The best estimates on numbers of physicians, incljding oteopaths, are "fiO'.OO in 1949, 264,000 in 1960 and 2SO.00O in 1963," the healih service sa d, "giving ratios of 144 3. .'44 2 and 145.9 physicians per 100,000 population in these respective years." The AMA said the 1963 ratio was 146.7 physicians for every 100,000 Americans, based on a physician population of 275,974. GEORGIA OFFICIAL CONVICTED WITH MOONSHINE RING COLUMBUS, Ga., Sept. 7 (AP) A member of the Georgia Legislature was convicted in United States district court yesterday of conspiring to manufacture and sell moonshine whisky. State Representative Joe Hurst of Quitman county, in South Georgia, who is serving his seventh term in the Legislature, was convicted with three other men. The others are Julian Ogletree, sheriff of Quitman county, Stanford Bennett, a farmer and Hubert Lynn. Sentencing was set for Friday. Hurst said that the convictions would be appealed. The sheriff admitted liquor dealing with Lynn but asserted that he entered into bootleg transactions to trap members of a Phenix City, Ala., liquor ring. Hurst denied that he had any connection with the other defendants in the liquor business. He said that he had no connection with the whisky business since he sold a liquor store in Georgetown, Ga., in 1942. COMMUNISM ATTACKED BY CARDINAL WYSZYNSKI WARSAW, Sept. 7 (AP) Cardinal Stefan Wyszynski declared in a veiled but strong attack on Communism tonight that "neither machine nor industrial combine can enslave men who have once stopped bowing to emperors and will never again agree to becoming enslaved." "We bishops and priests will encourage and stimulate" such resistance, the Polish primate said in a sermon to nearly 2000 worshippers at the consecration of the St. Stanislaw church in Warsaw. Cardinal Wyszynski said there can be no coexistence and peace until freedom, truth and justice are respected. pnucnlinn U1DC? IOWA GOVERNOR HIRES JUUAKU IU DAK VANUALo ,. nin iiuiiiilll DES MOINES, la., Sept. 7 (UPl)-Gov. Harold E. Hughes announced yesterday that he has hired an armed guard to patrol the grounds of the Governor's Mansion. Hughes said vandals and drunks have been roaming the grounds late at night, banging on doors, peeking in windows and tramping through flower beds. Also, Hughes said, he thinks someone has tapped his unlisted telephone line. S. Viet Nam FROM PAGE ONE release of 67 university student leaders still under arrest. Placards read: "U.S. Government does not help. President Kennedy will not help" and "U.S. Government Helps Diem. Do not help Diem." Some said, "Help us to fight for freedom," "Tell President Kennedy students do not like President Diem" and "Down with cruel Ngo family." Students, some of them clearly bitter at continued United States support for Diem, shouted at reporters, "Help us, help us." They appealed to the soldiers, "Long live army. Army does not fight students. Down with police." Aside from some marines, the only troops besides police were special forces units known for their loyalty to the Diem regime. The demonstrations erupted at various times in a three-hour peried at all five high schools before they were finally quelled. A small group tried to demonstrate at the main Saigon market but police broke it up. Single Protest Planned Viet Namese sources said the students had gone to their classes this morning with the intention of assembling at their respective schools, thtn marching through the streets to gather at one central point for a big demonstration. Police learned of their plan and trapped them inside and the demonstrations were held in the schools instead. The main demonstration occurred at the Vo Truong Tcan boys' high school near the Saigon zoo. Two hundred girls at the Trung Vuong government high school down the street also began shouting anti-government slogans until police moved in and took them away. UPI Telflol gave the final confirmation. The mystery of 10 year's standing was ended. Today the Department of Health, Education and Welfare called a press conference to an nounce the results. At the press conference, Dr. Wiley noted that it would be indeed difficult to extract creatine from horses. He said: "It would seem it was primarily an accident that would allow him to get any creatine at all from the process he used." SERVICE SWITCHES BANNED WASHINGTON, Sept. 7 (UPI) The Navy announced yesterday that it no longer will allow Annapolis graduates to be commissioned directly into the Army or Air Force. The recommendation had been made by the Naval Academy Board of Visitors. Last June, 74 of about 800 Naval Academy graduates were commissioned into the other two services. f Sv f V t ? V ;'f.M-1 By STUART H. LOORY T7J- .Ntr Tark Rn!4 Trltm Tort Dlwaf XtMWBl Dlipt'rtl WASHINGTON, Sept. 7-When Miss Ruth Kessler, a 20-year-old senior majoring in chemistry at the University of Pennsylvania, first discovered that the controversial ami -cancer drug Krebiozen and the common body chemical creatine seemed to be the same thing, she discarded the possibility. The discovery had been too easy. Miss Kessler, along with Steve Seater, another college student working this summer at the Food and Drug Administration, had been detailed under the direction of Oscar Sammul, an FDA scientist, to try to match the spectrograph of Krebiozen with one among the 20.000 chemical spectrographs on file. Krebiozen had been the source of scientific controversy for 10 years and in all that time no one had isolated the active ingredient in the mineral oil solution. Dr. Stevan Durovic, the drug's inventor, claims It arrests the course of cancer. Identity Sought Then the FDA, proceeding un-der the amendments to the food and drug laws that took effect early this summer, set out to identify the drug. Mrs. Alma Hayden, head of the spectrophotometry unit in the FDA's pharmaceutical chemistry division, assigned the three workers to search the spectrogram catalog, which consists of 20 volumes, each the size of an unabridged dictionary. "As a diversion, we discussed why ancient civilizations sprang up where they did," Sammul recalled today. "We had to take little breaks. After all, it was pretty monotonous work." They started in mid-afternoon one day last month and within a few hours, Miss Kessler, working her way doggedly through the "A"s and "B"s came across creatine under "C." A spectrogram is a page of steep curves obtained by shining infrared light through a sample of the chemical. Each chemical absorbs infrared of some wave-lengths and allows other wave-lengths to pass differently, giving a different set of peaks and valleys and providing a unique picture. The job confronting Miss Kessler, Sammul and Seater was to match the peaks and valleys of two different Krebiozen spectrographs one made by Dr. Durovic and the other by the Cancer Institute with the catalog. Samples Differed The two samples differed In minor detail because one was done on a Krebiozen sample that had absorbed some water and the other on one that was dehydrated. Miss Kessler looked at the creatine spectrogram in the book and then matched it with her two samples. Peak for peak, they appeared almost identical. "But it was so early. We had just started," she recalled. "I mentioned it to Steve and Oscar and we decided to keep looking. We thought maybe we might find another match." They worked until 3 p.m. quitting time and then they took the creatine spectrogram and one other downstairs to Mrs. Hayden. She noted the similarity between Krebiozen and creatine and after that the FDA really went to work. They wanted an airtight . identification. They wanted the association proved beyond the smallest shadow of a doubt. Why? Common Body Chemical Creatine is a common bodv chemical. The typical individual Krebiozen FROM PAGE ONE of an FDA team screening 20,-000 chemical spectograms, attempting to match them with an inirared picture of the Krebiozen sample. When writing for the FDA this summer. Miss Kessler finally matched the sample with the creatine spectogram, officials said. Boisfeuillet Jones, assistant to the Secretary of Welfare for health and medical affairs, said that two investigations have been under way, one by FDA intoNfce production and composition of the drug and the other by the National Cancer Institute into claims that the drug benefits human cancer patients. The nationwide facilities of FDA were used to obtain all possible data on 507 cases identified by Durovic and Ivy, Jones said, "as the best they had to offer showing the effectiveness of Krebiozen in cancer." An evaluation of these case records has been completed by the institute and a report on 22 cancer experts assembled by the findings is being prepared. It should be ready in 10 days. He said that the department first moved toward an investigation of Krebiozen in 1961 at the request of the late Judge Julius H. Miner of a United States district court in Chicago. Miner asked that the National Cancer Institute test Krebiozen because of a libel suit in Miner's court filed by Ivy against Dr. George D. Stoddard, who wrote a book about the drug. Food and Drug Commissioner George p. Larrick saod the entire MISS RUTH KESSLER, the University of Pennsylvania senior who identified Krebiozen as creatine, working in a laboratory at the university in Philadelphia yesterday. carries about four ounces of the chemical the equivalent of 12,-000,000 Krebiozen doses in his body at all times. It is manufactured as common sugar breaks down into chemicals that provide energy to the body. Creatine in combination with phosphorus provides muscles with the energy i they need to contract. And further, creatine can be purchased from chemical supply houses, which extract it from hamburger, at 30 cents a gram. Dr. Durovic has said that the production cost is $170,000 a gram. He makes it by injecting a chemical into horses and extracting the drug from their blood vessels. He says he could get only a few thousandths of a gram from a single horse. Although he never sold the drug, he asked donations of $9.50 a dose and Consumers Union has claimed the donations were often collectible C.O.D. "We were all pretty excited," Miss Kessler recalled of that day, "and then the next day I was pretty disappointed. I got sick and could not be in on the study." But Mrs. Hayden reported the finding to her superior, Dr. Frank H. Wiley, and the checking began. They bought samples of creatine and studied it by X-ray diffraction, under microscopes and in a device called a mass spectrograph. Then they were ready for the big test. Last Tuesday, the FDA assembled its experts, along with consultants from the National Cancer Institute, Massachusetts Institute of Technology and the universities of Maryland, New Mexico and Texas. An FDA inspector from Chicago entered the meeting room carrying a small plastic vial. In the vial was a sample of Krebiozen handed to the inspector by Dr. Durovic in Chicago on July 12 in the presence of witnesses. Sample Divided The vial contained about two milligrams of Krebiozen powder. "You really would have needed 20-20 vision to see that sample," Dr. Wiley said today. The FDA divided the sample, giving some record of Krebiozen was being examined with a view to "asking these people (its sponsors) to show cause why they should not be prosecuted in criminal court." He refused to be pinned down on specifics of any charge but suggested one might be based on data submitted to the government by the Krebiozen sponsors in an unsuccessful attempt to obtain a license for the drug. Dr. Frank H. Wiley, director of FDA's Division of Pharmaceutical Chemistry, said sponsors quoted to the Cancer Institute a cost figure of $170,000 a gram for Krebiozen but that he recently bought creatine at 30 cents a gram. FIRM RETURNS TO DETROIT AFTER 5 YEARS IN SOUTH DETROIT. Sept. 7 (AP)-After five years in the South the Crescent Brass & Pin Co. has returned to Detroit, where it operated previously for more than 50 years. Newton Skillman Jr., the new president, said the effort in the South did not work out. Crescent makes chaplets, used in the automobile industry. Chap-lets are metal parts that foundries need in pouring motor blocks of auto engines. The company, after 54 years in Detroit, moved to Americus, Ga., in 1958, hopeful of better profits. This did not result. Skillman said the necessary craftsmen for the plant's specialized operations were not available and there was no machine and tool shops to help out in event of trouble. He said the company lost 60 per cent of its auto industry busi-nesa when in the South. 5 to a team to perform an infra- red spectrograph that found the Krebiozen sample to be the same as creatine. Another small amount went to a microscopic crystallography team and it confirmed the findings Krebiozen and creatine are the same. A third team ran an X-ray crystallography test giving further confirmation. And a fourth team took a sample back to M.I.T. for a mass spectrographs test that FIDEL, RAUL AND ERNESTO , HAVANA, Sept. 7 (UPI) -Mrs. Norma Barban of Manzanil-lo gave birth to triplets and named the three boys Fidel, Raul and Ernesto, press dispatches reported today. They were named for Fidel and Raul Castro and Industries Minister Ernesto (Che) Guevara. 4 .J.' ., G iris Arrested in t V ;: ' .. 7:. v v ' f ,JJ -a. JTtt 3 T . '.It .i ..J S -miff .f jwl- m s- a Anti-Diem Demonstration rally at a high school in Saigon yesterday. Hundreds of itudents wera arrestad and taken to detention camps. South Viet Names soldiers circling a group of girls, clad in whit hatj and dresses, in an a nti government 1

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